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| Spectroscopy Spotlight |
Monitoring Enzymatic Transformation with NMR: Tracking Alanine Racemase Conversion of Substrate Chirality
An interview with Monique Chanhuot (Ecole Normale Supérieure, Paris, France) whose research interests include investigating enzymatic changes at a local scale using NMR. This interview discusses Chanhuot’s work with chiral liquid crystals in NMR to track changes in alanine chirality driven by alanine racemes. It is hoped that observations of chiral switching enzymatic activity using this method will help in the development of targeted and relevant antibiotics. MORE » |
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| Featured Articles |
Ion Mobility Spectrometry: Solo or Coupled to Mass Spectrometry
Ion mobility spectrometry (IMS) is a method for the separation of ions, which, as an analytical technique, has been applied for environmental monitoring, rapid security screening, and characterization of high mass biomolecular ions. In this column, we review the basics of IMS, describe field asymmetric ion mobility spectrometry (FAIMS), and discuss coupling FAIMS with mass spectrometry in an instrument that produces higher-dimensional data useful for the analysis of complex mixtures. MORE » |
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An Integrated Risk Assessment for Analytical Instruments and Computerized Laboratory Systems
A risk assessment is presented for determining the amount of qualification and validation work required to show that instruments and computerized laboratory systems are fit for their intended purpose. Risk management is one of the new requirements for the pharmaceutical industry following the publication of the Food and Drug Administration's (FDA) "Good Manufacturing Practices (GMPs) for the 21st Century" and the International Conference on Harmonization (ICH) Q9 on Quality Risk Management. MORE » |
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How to Select an ICP-MS System: Some Important Considerations
This article presents a set of evaluation guidelines — developed from the author's 20 years of experience demonstrating inductively coupled plasma–optical emission spectrometry (ICP-OES) and ICP–mass spectrometry (MS) instrumentation and running customer samples — to help laboratory scientists make the right decision when selecting an ICP-MS instrument. It focuses on the evaluation process and the most important factors to consider rather than on how to compare the analytical performance of the instruments being evaluated. MORE » |
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Surface-Enhanced Raman Scattering for Biofilm Characterization
Surface-enhanced Raman scattering (SERS) is a powerful technique for identification and characterization of biological molecules and biomolecular organizations. In this review, the effort to use SERS for in situ molecular characterization of biofilms is discussed. MORE » |
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Market Profile: Secondary Ion Mass Spectrometry
Although mass spectrometers are more commonly associated with life science applications, there are some mass spectrometry (MS) techniques that are specifically designed for surface science applications. MORE » |
| Featured Products |
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Broadband fibers by Avantes
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Integrated Raman System
The IDRaman reader from Ocean Optics is an integrated Raman system with Raster Orbital Scanning, an innovative sampling technique that enables more efficient Raman signal collection with lower background effects. www.oceanoptics.com/idraman/reader.asp |
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Quality data, quality answers with Nicolet iN10 FT-IR Microscope
With its intuitive, innovative design, combined with its novel approach to instrument operation, the Thermo Scientific™ Nicolet™ iN™10 Infrared microscope accelerates workflows for users in analytical, forensic or research labs. www.thermoscientific.com/in10 |
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| On Demand Webcasts |
High Speed AFM-Raman Optimized for Nanoscale Chemical Imaging: Making TERS An Accessible Technique
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Editors’ Series: Sample Introduction for ICP-OES and ICP-MS: From Basic Concepts to Practical Considerations
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Editors’ Series: Environmental Analysis Using Ion Chromatography Coupled with ICP-MS, with Examples from Climate Change Studies
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