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LCGC Europe - News Bulletin
11 September 2014

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Top Story: Current Practices and Considerations for a Stability-Indicating Method in Pharmaceutical Analysis
The demonstration of drug substance (DS) or drug product (DP) stability over the shelf life is a regulatory requirement in the pharmaceutical industry. To fulfill this requirement, a stability-indicating method (SIM) must be developed and validated to separate and quantify both the active pharmaceutical ingredient (API) and its related compounds (process impurities and degradation products).
Fast, Reliable Glycan Mapping
New Agilent AdvanceBio Glycan Mapping columns obtain high-resolution, reliable glycan maps in LESS THAN 10 MINUTES with 1.8 µm particles. 2.7 µm particles offer high resolution with lower backpressure, 1.8 µm for highest UHPLC resolution. Each batch of media is QA tested with a glycan sample to ensure consistent quality and robust performance. Glycan standards are available for performance testing and retention mapping. Learn More
LCGC TV: Mary Ellen McNally on Maintaining Precision During Method Transfer
Transferring methods between laboratories can be extremely difficult. In this new short video from LCGC TV, Mary Ellen McNally from DuPont Crop Protection gives her advice on best practices for maintaining precision during method transfer.

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LCGC Europe Supplement: Advances in Food Analysis
Food provides the body with energy, and good food is indispensable for a healthy life. With a worldwide population of over seven billion people, it is clear that state-of-the art technology is needed to provide food of a sufficient high quality.
All You Expect, And More
The next generation of Agilent UHPLC is coming.
See the launch at Analytica China, Shanghai, September 24 -26, 2014
Determination of Corrosion Inhibitor–Lubricity Improver in Jet Fuels by Liquid Chromatography–Electrospray Ionization Mass Spectrometry
Military jet fuel is very similar to commercial jet fuel except for the presence of three additives. Of particular interest is the CI-LI additive; the most common active ingredient is a dimer of linoleic acid. This article focuses on quantification of the active ingredient in the CI-LI additive by liquid chromatography–mass spectrometry (LC–MS), to allow the determination of CI-LI content in military jet fuel samples.
Need GC Troubleshooting Help?
The CHROMacademy interactive GC Troubleshooter, sponsored by Thermo Scientific, was designed with busy chromatographers in mind. In 3 simple steps ChromAcademy can help you overcome your instrument, separation and quantitation issues. It’s completely free — so if you haven't tried our troubleshooter before you're in for a surprise! Learn More

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News: Chiral Separation of I-MAMP and d-MAMP in Saliva
Scientists from the National Institute on Drug Abuse (Maryland, USA) and the University of Maryland Baltimore (Maryland, USA) have proposed precolumn derivatization using N(α)-(2,4-dinitro-5-fluorophenyl)-l-alaninamide (Marfey’s reagent) prior to LC–MS analysis for the quantitation of chiral amphetamines in plasma and saliva.

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Entering the Second Dimension
Michael Frank, Senior Director of Global Marketing, Liquid Phase Separation Business at Agilent Technologies, talks about the rise of two-dimensional liquid chromatography (2D LC) and its potential for routine analysis.
Upcoming Webcasts
Utilizing PepFinder Software for Interrogation of LC–MS Peptide Map Data of Biotherapeutics
Thursday 17 September 2014 8:00 AM PDT/ 11:00 AM EDT/ 4:00 PM BST/ 5:00 PM CEST
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Automated Solid-Phase Extraction for the Environmental Testing Laboratory
Wednesday 24 September 2014 8:00 AM PDT/ 11:00 AM EDT/ 4:00 PM BST/ 5:00 PM CEST
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Pushing the Limits of Chromatography with Next Generation UHPLC Technologies: How Solid Core Column and Advanced UHPLC Technologies Change the Landscape in LC Labs
Thursday 25 September 2014 8:00 AM PDT/ 11:00 AM EDT/ 4:00 PM BST/ 5:00 PM CEST
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