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31 May 2013
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| In this Issue |
Things You Should Know About Your HPLC Column
The physical characteristics of silica-based HPLC columns can affect the performance of the separation almost as much as the bonded phase. This instalment of the LCGC Blog re-visits some of the lesser-known facts relating to silica particles used for chromatography. More... |
| Agilent Technologies |
 Perform Trace-Level Analysis With Confidence
Ensure a reliably inert GC flow path for higher sensitivity, accuracy, and reproducibility… especially at trace levels with the new Agilent Inert Flow Path Solutions  Get the poster.
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Agilent Technologies Joins Forces with the University of Rouen and A*STAR to Focus on Biologics
Agilent Technologies (Santa Clara, California, USA) has teamed up with the Glyco-MEV laboratory at the University of Rouen (Rouen, France) and the Bioprocessing Technology Institute (BTI) at the Agency for Science, Technology and Research (A*STAR) (Singapore) to sign a memorandum of understanding to develop tools to analyse biologics and vaccines. More... |
| Merck Millipore |
 The Samplicity® system provides a higher-throughput, ergonomic alternative to syringe filters for preparing liquid chromatography samples. The vacuum-driven system simultaneously filters up to 8 samples in seconds, including hard-to-filter samples. Learn more |
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Improving the Taste of Tomatoes Using GC–MS
The preservation of food at home is a major concern for all consumers. A group of researchers from INRA in Avignon, France, have conducted a study into tomato aroma with the aim of finding the optimum conditions for storage. More... |
| CHROMacademy |
 5 Years Free Access to CHROMacademy
To show our commitment to learning, we have decided to offer all university students and staff free access to CHROMacademy. You are the future leaders and innovators of the scientific community, and by offering free access to CHROMacademy we hope to help you realize your potential. This has been made possible by Agilent Technologies- the world’s premiere measurement company.
 Learn More |
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| Current features |
Advances in Supercritical Fluid Chromatography for the Analysis of Chiral and Achiral Pharmaceuticals
A revival of supercritical fluid chromatography (SFC) has been observed recently. SFC has repeatedly enabled fast and efficient separations, and in some cases has even outperformed high performance liquid chromatography (HPLC). This article provides an overview of the most recent advances in the field of chiral and achiral separations in SFC. This involves research focused on the most critical parameters in SFC separations, but also on practical issues such as the serial coupling of columns. The recent evolution from classic SFC to ultrahigh-performance supercritical fluid chromatography (UPSFC) is also discussed. More... |
Automated MAb Workflow: From Harvest Cell Culture to Intact Mass Analysis of Variants
Recombinant monoclonal antibodies (MAbs) are a growing class of therapeutic molecules. Early in the development of MAbs, a large number of harvest cell culture (HCC) samples must be screened for immunoglobulin G (IgG) titer, aggregations, and charge variants. This study describes a two-dimensional (2D) high performance liquid chromatography (HPLC) workflow for affinity, size-exclusion, and ion-exchange analysis. More... |
| Application Note |
Simplifying Complex Multi-Residue Pesticide GC-MS/MS Methodology
David Steiniger, Juan Carmona, Stacy Crain, Paul Silcock, and Jason Cole, Thermo Fisher Scientific
Ease the implementation and management of multi-residue pesticide methodologies with a comprehensive solution that enables quick and easy method development regardless of method complexity and experience level of the user to eliminate days, if not weeks, from normal development time. More... |
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| Multimedia |
| Tips and Tricks on Screening and Confirmatory Methods for Residues and Contaminants in Foods |
| Editors' Series: A Generic HPLC–UV Platform Method for Cleaning Verification |
| The CHROMacademy Essential Guide: GC–MS/MS Analysis – What you need to know! |
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Need LC Troubleshooting Help?
CHROMacademy has developed the HPLC Troubleshooter with busy chromatographers in mind. Sponsored by Thermo Scientific, in 3 simple steps you will overcome your instrument, separation and quantitation issues. It’s completely free - so if you haven't tried our troubleshooter before you're in for a surprise!
 http://bit.ly/LC_Troubleshooting |
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| The Column |
 The Global E-zine for Separation Scientists
The global edition of The Column is delivered twice monthly with a screen-optimized format designed to improve readability. Covering topical issues, application-based articles, market reports, tips and tricks, opinion pieces and interviews, The Column is a great information resource helping readers achieve better day-to-day working practices.
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