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August 22, 2013
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Chromatography Corner

Trends in Pharmaceutical Analysis: A Technology Forum
LCGC spoke with experts in the pharmaceutical industry about current and emerging trends in pharmaceutical analysis, including the use of LC-MS instead of LC-UV for routine assays, best practices for impurity profiling, and areas where commonly used methods are likely to improve.
New LC-MS for Pharma Applications
The Thermo Scientific™ Orbitrap Fusion™ Tribrid™ mass spectrometer uses the power of three mass analyzers and multiple fragmentation modes to deliver fast, unambiguous structural elucidation and more definitive identification of small molecules. For targeted quantitation in bioanalysis or process monitoring, the Thermo Scientific™ TSQ Quantiva™ triple quadrupole MS provides the extreme sub-attomole sensitivity and speed needed for quantitation of low level compounds in complex matrices. Learn More
Chromatography News

Researchers Compare Configurations for Two-Dimensional LC for the Analysis of Peptides
In new research, separation scientists from the University of Lyon, France, have compared different configurations of on-line two-dimensional liquid chromatography (2D LC) for the separation of charged compounds such as peptides.
LC Troubleshooting

Need Help With LC Troubleshooting?
A free interactive LC Troubleshooter is now available at CHROMacademy, sponsored by Thermo Scientific. In 3 simple steps you will overcome your instrument, separation and quantitation issues. It's completely free.
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High-Throughput Volatiles Determinations
Experience high-throughput volatiles determinations and reliable operations with unparalleled flexibility. The new Thermo Scientific™ TriPlus™ 300 Headspace Autosampler offers a quick start-up and enables reliable, unattended and high throughput operations with expanded sample capacity.
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New Webcasts
Analysis of Post-translational Modifications Using LC–MS-MS
Thursday, August 22, 2013
8:00 am PDT/11 am EDT/16:00BST/17:00 CEDT.
In this session, Dr Duncan Smith  and Dr John Griffiths (MS-Insight Ltd and Manchester University) explain the principles behind the analysis of a number of key post-translational modifications (PTMs) using LC-MS/MS techniques.
Recent Developments in Protein Glycosylation Analysis by HPLC with Charged Aerosol and Mass Spectrometric Detection
Tuesday, September 17, 2013
8:00 am PDT/ 11:00 am EDT/ 16:00 BST/ 17:00 CEDT.
This web seminar will discuss promising improvements to glycosylation analysis that couple unique HPLC stationary phases with direct measurement of glycans by charged aerosol detection and with flow-splitting for simultaneous mass spectrometry MS-MS detection. These strategies avoid problematic O-linked glycan degradation (“peeling”) associated with some other quantitative methods, and employs optimal conditions for heightened characterization using additional offline MS techniques for characterization.
Upcoming Events

25–28 August 2013
AOAC 127th Annual Meeting & Exposition
Chicago, IL
» Visit the website
16–18 September 2013
Applied Pharmaceutical Analysis
Boston, MA
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20 September–4 October 2013
SciX 2013 - The Great SCIentific eXchange
Milwaukee, WI USA
» Visit the website
23–25 September 2013
Polyurethanes 2013
Phoenix, AZ
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23–26 September 2013
10th Symposium on the Practical Applications of Mass Spectrometry in the Biotechnology Industry
Boston, MA
» Visit the website
24–26 September 2013
Analitica South America
Sao Paulo, SP., Brazil
» Visit the website