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June 12, 2014
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Featured Video

Should you be using GCxGC in your routine analysis?
Two-dimensional gas chromatography (GCxGC) started out as a specialized technique reserved for the domain of academic researchers. But the technique, and the instrumentation, have evolved significantly in the past decade. Does it make sense to use GCxGC in routine analysis? Frank Dorman weighs in.  More...
Better Methods with DryLab
For over 25 years, DryLab has been the leading software solution for HPLC method development.  DryLab works with all chromatography data systems and uses real data to predict chromatograms under a much wider range of experimental conditions than would ever be possible in the laboratory.  Anybody working in the realm of HPLC who wishes to optimize complex samples and to economize resources spent developing and running methods will benefit from using DryLab. Learn more
The LCGC Blog

The LCGC Blog: Chromatography Technical Tips - Robustness in HPLC Eluents
The ultimately robust HPLC mobile phase is 0.1% TFA (aq) / 0.1% TFA in Acetonitrile, right? Maybe. It would be great if we had arrived at a “global” HPLC mobile phase – but we haven’t, and here’s why, alongside some suggestions on achieving high quality separations with robust eluent systems. When developing a separation, some fundamental choices need to be made on how we might achieve the separation we require – primarily the mode of chromatography used and the way in which we intend to control and optimize the retention and separation (selectivity) of analyte components.  More...
SYNAPT G2-Si  Redefining Resolution
There are three dimensions of resolution. SYNAPT G2-Si is the only way to view them all. Chromatography. Mobility. Mass. Sometimes mass resolution and chromatography are not enough. With high-efficiency ion mobility, you can use an additional dimension of separation, based on molecular size and shape. That's SYNAPT G2-Si High Definition MS. And it delivers the highest levels of selectivity and peak capacity without compromise. Learn more
Readers' Questions: Calibration
LC Troubleshooting columnist John Dolan provides answers to readers’ questions about two topics related to method calibration: “What’s the matter with the calibrators?” and “When should an internal standard be used?”  More...
Introducing: Lab Water Solution Center
The Lab Water Solution Center, developed by LCGC in coordination with EMD Millipore, can help you process and manage your lab water solutions by providing a variety of articles, webinars, videos, and other resources on lab water — updated monthly. Visit to find these resources and more
GC Troubleshooting

Need Help With GC Troubleshooting?
A free interactive GC Troubleshooter is now available at CHROMacademy, sponsored by Thermo Scientific. In three simple steps you will overcome your instrument, separation and quantitation issues. It's completely free. More...
Find the Right Columns for Your Needs
We all know that chromatography— including how to choose the right column for your application — is full of complexity. The Chromatography Solutions Center is here to help. The Solution Center, developed by LCGC in coordination with Thermo Scientific, can help you find answers to your analytical challenges by providing a variety of articles, application notes, videos, and other resources - updated monthly. Check out this month's installment of the Columns and Consumables section.
Featured Products

Automated Sample Cleanup for POPs analysis
The PowerPrep® Multi-Column Sample Cleanup System is designed specifically to automate the difficult, error prone, labor intensive manual processes involved in sample cleanup for trace analysis.
More information.
Sensitive, Ultrafast LCMS
Utilizing patented ultrafast technology, Shimadzu’s single-quad LCMS-2020 offers faster measurements and higher detection sensitivity for quicker and more accurate detection of trace impurities in a variety of applications.
Learn more
The First SEC-MALS detector for UHPLC
The µDAWN is the world’s first multi-angle light scattering (MALS) detector that can be coupled to any UHPLC system in order to determine absolute molecular weights and sizes of polymers, peptides, and proteins.
Learn more
On Demand Webcasts

Editors' Series: Exploiting Recent Development in HPLC and MS for Improved Polyphenol Analysis Shimadzu
Monoclonal antibodies complete primary structure and biosimilarity assessment in a single analysis using CESI–MS-MS
Fast, Robust LC and LCMS Workflows for the Comprehensive Characterization of Bio-Therapeutic Proteins Thermo Fisher Scientific
Features of Different Mass Analysers Applied to Multi-Allergen Screening
Part Three: Editors' Series: Analysis and Identification of Emerging Contaminants and their Transformation Products in River Water, Urban Water, and Hospital Wastewaters: Sample Preparation and LC-MS Techniques
New Webcasts
Suitability of Ionic Liquid GC Columns for Various Applications
Thursday, June 12, 2014 8:00 AM PDT/ 10:00 AM CDT/ 11:00 AM EDT
Enhanced Detection and Confirmation in Forensic Toxicology Screening Using a UHPLC-QTOF System
Friday, June 13 , 2014 8:00 AM PDT/ 10:00 AM CDT/ 11:00 AM EDT
From TLC to Flash to Prep-HPLC on BUCHI’s new All-In-One Solution – PrepChrom C-700
Wednesday, June 18 , 2014 8:00 AM PDT/ 10:00 AM CDT/ 11:00 AM EDT
LC Troubleshooting 3.0 – The Smart Art of LC Troubleshooting Automation
Tuesday, July 1 , 2014 8:00 AM PDT/ 11:00 AM EDT/ 4:00 PM BST/ 5:00 PM CEST
Polymer Characterization Using Multi-Detector Ambient and High Temperature Gel Permeation Chromatography
Wednesday, July 23, 2014 8:00 AM PDT/ 11:00 AM EDT/ 4:00 PM BST/ 5:00 PM CEST