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April 3, 2014
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Featured Article

LC Method Scaling, Part I: Isocratic Separations
Isocratic separations, in which the mobile-phase concentration is constant, are simpler to convert than gradient methods, where special care has to be taken to avoid inadvertent chromatographic changes. This installment of "LC Troubleshooting" focuses on isocratic separations.  More...
Streamline Your Drinking Water Extractions and Analysis
Recent advances in solid phase packing materials and new technologies in automating the extraction and concentration process are making the Drinking Water sample prep and analysis workflow a more robust, efficient process yielding higher throughput and more consistent results. To learn more Register for a free webinar May 7th, 2014 11:00 am EST.
Milton Lee on the Potential of Thermal Gradient Gas Chromatography (TGGC)
Thermal gradient gas chromatography (TGGC) was first developed in the 1960s to reduce the effects of peak broadening. With recent developments in technology, the technique is now being re-examined. In two new videos from LCGC TV, Milton L. Lee from Brigham Young University discusses the principles of TGGC, and the possible advantages of TGGC  over traditional GC methods.
LiChrosolv® Solvents for Liquid Chromatography
With their low particle count, low acidity and alkalinity and low evaporation residue level, LiChrosolv® solvents are ideal for reproducible separations. Since separations are normally carried out under gradient conditions in analytical HPLC, we offer solvents in ‘gradient grade’ as well as ‘isocratic grade’. This enables you to minimize the gradient effect of the solvent involved – for example in enantiomeric separations on chiral phases. Learn more
Mass Spectrometry for Natural Products Research: Challenges, Pitfalls, and Opportunities
A common attitude in natural products research is that nuclear magnetic resonance (NMR) spectroscopy serves as a primary tool, whereas mass spectrometry (MS) is relegated to the task of providing the molecular formulas of pure compounds. Yet over the past several decades, we have witnessed astonishing growth in MS. Electrospray ionization has enabled the analysis of biological molecules previously deemed intractable, and instruments that offer astounding mass accuracy are becoming routinely available. Nonetheless, as applied to natural products research, MS is still fraught with challenges and pitfalls. Here is an account of strategies to conduct effective research despite these obstacles.  More...
Solutions to Your Challenges in Ion Chromatography
We all know that chromatography is full of complexity. The Chromatography Solution Center is here to help. Check out this month’s installment of the Ion Chromatography section, featuring Practical and Popular Sample Prep Techniques for IC, Speciation Applications Summary IC, IC webinar, application note, white paper, and more. Learn more
GC in Forensic Laboratories
Tom Brettell, an associate professor of chemistry at Cedar Crest College, recently conducted a survey of gas chromatography column use in forensic laboratories in the United States. Here is what he found, in terms of the types of columns they are using and the problems they face. More...
Waters introduces the ACQUITY QDa Detector
The future is now separated from the past.  Imagine a lab where all analytical scientists can acquire high–quality mass spectral data. On their own. Within their existing workflows. Across every sample. Without training. Waters imagined just that and introduces the ACQUITY QDa Detector. Click Here
LC Troubleshooting

Need Help With LC Troubleshooting?
A free interactive LC Troubleshooter is now available at CHROMacademy, sponsored by Thermo Scientific. In three simple steps you will overcome your instrument, separation and quantitation issues. It's completely free. More...
New Webcasts

HPLC for Pharmaceutical Analyses: Succeed with Sample Filtration and Optimized Water Quality
Wednesday, April 9, 2014 8:00 AM PDT/ 11:00 AM EDT
Do you perform HPLC in a pharmaceutical discovery or development operation? Attend this webinar, and you’ll learn valuable strategies for maintaining clean baselines, improving run reproducibility, and prolonging column life. Our speakers will guide you through choosing the sample filtration platform to match your workflow stage and throughput needs and understanding the impact of water quality on chromatography results.
High Resolution MS Screening and Quantitation Method for Contaminants in Dietary Supplements
Thursday, April 10, 2014 8:00 AM PDT/ 11:00 AM EDT/ 4:00 PM BST/ 5:00 PM CEST
Learn from the FDA’s Lukas Vaclavik about the analysis of pharmaceutical and plant toxin contaminants in herbal dietary supplements.
Editors’ Series: Investigating the Potential Impact of Hydraulic Fracturing on Private Well Water Quality
Thursday, May 8, 2014 8:00 am PDT/ 10:00 AM CDT/ 11:00 AM EDT
Until now, limited studies have been performed regarding the environmental impact of hydraulic fracturing for harvesting natural gas. In this seminar, Kevin Schug discusses the suite of analytical methods (including headspace-GC, GC-MS, ICP-OES, ICP-MS, total organic carbon, and ion chromatography methods) his team developed to evaluate the quality of private well water in proximity to natural gas extraction sites. This talk will report on the results of their studies to date, future plans, and the opportunity presented by his baseline studies of future fracking sites.
Upcoming Events

11–15 May 2014
HPLC 2014
New Orleans, LA
» Visit the website
18–23 May 2014
38th International Symposium On Capillary Chromatography and the 11th GCxGC Symposium
Riva del Garda, Italy
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25–28 May 2014
ExTech 2014
Chania, Crete, Greece
» Visit the website
20–23 July 2014
PREP 2014 Symposium on Preparative and Process Chromatography
Boston, MA
» Visit the website