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January 17, 2014
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LCGC TV Featured Video

Keys to Developing a Method for 2D Liquid Chromatography
Two-dimensional liquid chromatography (2D LC) is becoming more widespread but still poses challenges, particularly for those new to the technique. In a new interview, Dwight Stoll of Gustavus Adolphus provides advice about key decisions in method development, common errors to avoid, and other advice for getting started with 2D LC. More...
Advance Protein Characterization
Resolve and identify critical peptides in a digest with Agilent AdvanceBio Peptide Mapping columns, specially tested with a demanding peptide mix to ensure reliable peptide mapping performance. Explore AdvanceBio columns for LC/MS and LC/UV, and take your characterization further. Get tips and advice.
Featured Articles

Practical Tips for Operating UHPLC Instruments and Columns
This article describes the design of modern UHPLC instruments and offers simple procedures to identify the causes of poor column and method performance. Modern textbooks do not yet adequately address the complex topic of UHPLC, therefore the reader is encouraged to collect all references to learn important, additional details. More...
Sensitive, Ultrafast GC/MS/MS
The only GC/MS/MS capable of running all triple quad operational modes, without sacrificing sensitivity or accuracy, Shimadzu’s GCMS-TQ8030 elevates this method to a new level of performance. Fast enough for MRM/Scan and GC x GCMS, it features a true scan speed of 20,000 u/second and 600 MRM transitions/second. In addition, high-sensitivity ion optics eliminate neutral noise and maximize signal intensity for ultimate S/N ratio. Learn more
Back to the Basics: Considering Carryover, Column Back Pressure, and Wavelength When Developing Chromatographic Methods
High performance liquid chromatography (HPLC) is a sophisticated technique. Chromatographers must not forget the basics of method development to reap the full benefits in practice. Obvious parameters to optimize include the choice of chromatographic column, mobile phase, injection volume, flow rate, and detector settings. However, it is also beneficial to know how to determine carryover, the properties of the needle wash solvent used, and the importance of monitoring instrument back pressure. This article discusses issues related to carryover, instrument back pressure, and the choice of wavelength. More...
Simplified HILIC separations from a world leader in HILIC
New, eHILIC chemistry from The Nest Group, Inc. addresses both acidic and basic, polar analyte separation challenges. Whether the goal is to reduce their interaction or enhance it, our ERLIC capability facilitates separations by polar differences. Try our ERLIC separationapproaches today! The Nest Group, Inc. - "Not Just Columns ... Answers!".
Optimizing GC–MS Methods
There are many "minor" variables in gas chromatography–mass spectrometry (GC–MS) analysis that can be optimized to improve selectivity or sensitivity, and knowledge of these is important in getting the most from your analytical methods. What follows is a brief summary of some of the simpler ways to improve your GC–MS analyses. More...
CALL FOR PAPERS on biochromatography, QbD, monoclonal antibodies, VLPs, and other biopharmaceuticals, chiral molecules, SFC, fine chemicals, SMB, APIs, monoliths and new stationary phases, and more! 60+ oral presentations, 2-day Poster Session, 2½-day Exhibit, and Workshops. The most recognized international meeting covering the latest developments in preparative and process liquid chromatography, separation science and technology, PREP-2014, July 20-23 in
LC Troubleshooting

Need Help With LC Troubleshooting?
A free interactive LC Troubleshooter is now available at CHROMacademy, sponsored by Thermo Scientific. In 3 simple steps you will overcome your instrument, separation and quantitation issues. It's completely free. More...
Waters introduces the ACQUITY QDa Detector
The future is now separated from the past. Imagine a lab where all analytical scientists can acquire high-quality mass spectral data. On their own. Within their existing workflows. Across every sample. Without training. Waters imagined just that and introduces the ACQUITY QDa Detector. Click Here
New Webcasts

Editors Series’: Analytical Tools for the Characterization of Biopharmaceuticals: Part 1: Chromatographic Methods
Wednesday, January 22, 2014, 8:00 AM PST; 11:00 AM EST
Tune into this two-part web seminar to learn the latest developments in HPLC and MS for biopharmaceutical characterization, including the potential and limitations of various approaches.
Multi-Analyte Analysis of 390 Pesticide Residues, Mycotoxins, and Pyrrolizidine Alkaloids in Phytopharmaceuticals, and Herbal Food Supplements with UHPLC–HRAM–MS/MS
Tuesday, February, 4, 2014, 8:00am PST/ 11:00 AM EST/ 4:00 PM GMT
Join this webinar describing a multi-analyte method for target analysis of >380 pesticide residues, mycotoxins and pyrrolizidine alkaloids using a QuEChERS extraction method and UHPLC–HRAM–MS/MS technology.
Editors Series’: Analytical Tools for the Characterization of Biopharmaceuticals: Part II: Mass Spectrometry Detection
Wednesday, February 5, 2014, 8:00 AM PST; 11:00 AM EST
Tune into this two-part web seminar to learn the latest developments in HPLC and MS for biopharmaceutical characterization, including the potential and limitations of various approaches.
Multi-Antibiotic Residue Detection in Food:An Improved Method for Screening and Confirmation Testing, in Accordance with EU Commission Decision 2002/657/EC
Tuesday, February, 18, 2014, 8:00 am PST/ 11:00 AM EST/ 4:00 PM GMT
Speed up your veterinary drug residue screening with high-resolution accurate mass LC-MS.  Validated in accordance with EU Commission Decision 2002/657/EC, this new screening, quantitative and confirmatory method can be applied to meat and fish and covers more than 100 compounds including all relevant antibiotics, anthelmintics, and antiparasitics. Join the webinar to learn more.
Upcoming Events

18-22 January 2014
SLAS 2014
San Diego, CA
» Visit the website
28–31 January 2014
HTC-13 & HTSP-3
Bruges, Belgium
» Visit the website
20 February 2014
Wyatt Technology San Francisco Bay Area Protein & Biotech Users Meeting
Burlingame, CA
» Visit the website
2–6 March 2014
Chicago, IL
» Visit the website
12–14 March 2014
Eurolab 2014
Warsaw, Poland
» Visit the website
18–23 May 2014
38th International Symposium On Capillary Chromatography and the 11th GCxGC Symposium
Riva del Garda, Italy
» Visit the website
25–28 May 2014
ExTech 2014
Chania, Crete, Greece
» Visit the website
20–23 July 2014
PREP 2014 Symposium on Preparative and Process Chromatography
Boston, MA
» Visit the website