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February 25, 2014
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Chromatography Corner

Current Trends in Chiral Chromatography
More than 60% of newly commercialized drugs possess chiral properties, and this is set to grow as the biopharmaceutical industry flourishes. Professor Debby Mangelings from the Vrije Universiteit in Belgium, spoke to LCGC about the importance of chiral chromatography in pharmaceutical analysis, the challenges facing analysts, and where the field is headed next.
Monoclonal antibodies (mAbs) are one of the fastest growing classes of pharmaceutical products. They play a major role in the treatment of a variety of conditions such as cancer, infectious diseases, allergies, inflammation, and auto-immune diseases. In this application note, the capabilities and performance of an Orbitrap based mass spectrometer in analyzing the intact and reduced forms of rituximab (a monoclonal antibody) are demonstrated. Learn more
Featured News

Principal Component Analysis with LC–MS Enhances Natural Drug Discovery Process
Scientists in Malaysia have developed a useful metabolomics approach that could aid analysts working in natural drug discovery. The team applied liquid chromatography–mass spectrometry (LC–MS) coupled with principle component analysis (PCA) to screen more than 4000 natural extracts for novel photosensitizer drugs.
Chromatography Solution Center

Resources for Pharma Analysis
We all know that pharmaceutical analysis is full of complexity. The Chromatography Solution Center, developed by LCGC in coordination with a leading supplier, can help — by providing a variety of articles, application notes, videos, and other resources — updated monthly. This month's offering includes advice on:
How the analysis of biomolecules benefits from UHPLC

Analyzing residual solvents in pharmaceutical products using GC headspace with valve-and-loop sampling

How to gain significant efficiencies in pharmaceutical and biopharmaceutical manufacturing
Featured Product

Next Generation Charged Aerosol Detection
Get improved sensitivity for semivolatile compounds, HPLC/UHPLC compatibility, and a wide flow-rate range in a universal detector. The Thermo Scientific™ Dionex™ Corona™ Veo™ Charged Aerosol Detector can be used with LC capillary, micro-bore and normal-bore columns for unprecedented application flexibility. See what other detectors are missing!


New Webcast
The Use of Solid Core Technology in the Pharmaceutical Environment
Thursday, March 25, 2014
8:00 AM PDT/ 11:00 AM EDT/ 3:00 PM GMT
This webinar will provide the tools for successful introduction of solid core chromatography. It will explain how the technology works and which columns to choose for specific areas and stages in the pharmaceutical pipeline.
Upcoming Event

2–6 March 2014
Chicago, IL
» Visit the website
12–14 March 2014
Eurolab 2014
Warsaw, Poland
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18–23 May 2014
38th International Symposium On Capillary Chromatography and the 11th GCxGC Symposium
Riva del Garda, Italy
» Visit the website
25–28 May 2014
ExTech 2014
Chania, Crete, Greece
» Visit the website
20–23 July 2014
PREP 2014 Symposium on Preparative and Process Chromatography
Boston, MA
» Visit the website