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LCGC North America
June 13, 2017
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Spectroscopy Spotlight

Quantitative Drug Metabolite Profiling without Radiolabels Using HPLC–ICP-MS

In drug development, quantitative determination of a candidate drug and its metabolites in biofluids is an important step. The standard technique for quantitative metabolite profiling is radiolabeling followed by high performance liquid chromatography (HPLC) with radiodetection, but there are disadvantages to this approach, including cost and time, as well as safety and ethical concerns related to administering radiolabeled compounds to humans. Frank Vanhaecke and his research group at Ghent University have been developing an alternative technique, and he recently spoke to Spectroscopy about this work. read more

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Featured Articles

Laser Ablation and Inductively Coupled Plasma–Time-of-Flight Mass Spectrometry—A Powerful Combination for High-Speed Multielemental Imaging on the Micrometer Scale

This study demonstrates a new imaging approach by coupling LA with ICP-TOF-MS in two application areas: geology and biology. read more


The SuperCam Remote Sensing Instrument Suite for the Mars 2020 Rover: A Preview

Take a peek into the plans for the SuperCam remote sensing instrument suite for NASA's Mars 2020 Rover mission. read more


The Application of Computational Chemistry to Problems in Mass Spectrometry

With computational chemistry, chemists can now study chemical phenomena by performing computationally intense calculations on computers rather than examining reactions and compounds experimentally. This is especially attractive when the laboratory experiments are time consuming, costly, dangerous, or difficult. Modern computational chemistry tools are capable of determining molecular structures, molecular spectra, and energetics, and of elucidating reaction pathways and chemical reaction products. read more

Application Note

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Simultaneous determination of hydride and non-hydride elements in fish samples using the Agilent 5110 SVDV ICP-OES with MSIS accessory

Agilent's Multimode Sample Introduction System (MSIS) is a flexible sample introduction system for the determination of hydride and non-hydride elements by ICP-OES. It can be operated in three modes: conventional nebulization mode, vapor generation mode or dual mode. In dual mode both hydride and non-hydride elements can be measured at the same time, eliminating complicated, time consuming sample introduction changeovers without sacrificing sensitivity to reduce instrument downtime. Register now


More Featured Article

Review of New Spectroscopic Instrumentation for 2017

Our annual review of new spectroscopy products introduced at Pittcon, or during the previous year. read more


Quiz

IR Spectral Interpretation Workshop, Quiz 11

This quiz is a regular feature of the “IR Spectral Interpretation Workshop” column. In each installment, we present a quiz. The answers appear in the subsequent installment. (For previous quiz questions and answers, click here.) read more

FEATURED PRODUCTS

New Era in Photoluminescence Launched

The newly launched FLS1000 sets the standard in both steady state and time-resolved photoluminescence spectroscopy for both fundamental research and routine laboratory applications. Learn more

NEW 6th Gen MiniFlex - Benchtop XRD

New 6th generation MiniFlex XRD system delivers speed and sensitivity through innovative technology advances, including the HyPix-400 MF 2D hybrid pixel array detector (HPAD) together with an available 600W X-ray source and new 8-position automatic sample changer. Learn more

Easy, high-performance spectroscopy

High-performance spectroscopy can be easy! Simply plug in the FERGIE system from Princeton Instruments and start your work; no calibrating, no aligning, no guessing. Watch the videos to learn more.


NEW WEBCASTS

Finding the Right Solution for Your Laboratory: A Comprehensive Guide to Trace Elemental Analysis Instrumentation – Part II (ICP-MS)

Tuesday, June 13, 2017
11 am EDT | 8 am PDT | 4 pm BST | 5 pm CEST

How to Achieve Valid Results First Time, Every Time with ICP Techniques

Tuesday, June 27, 2017
11 am EDT | 10 am CDT | 8 am PDT

ON DEMAND WEBCASTs

Difficult Sample Analysis Made Simple for ICP-OES


Trace Element Analysis Using ICP-MS for Environmental Samples - Regulations and Routine Monitoring


Why it’s Vital to Measure Elemental Components in Wine, Whiskey, and Beer: Elemental Analysis to Assess Safety, Authenticity, Quality, and Nutrition


Finding the Right Solution for Your Laboratory: A Comprehensive Guide to Trace Elemental Analysis Instrumentation - Part I (ICP-OES & AAS)

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