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March 24, 2015
Presented by LCGC and Spectroscopy

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Stuart Gregory/Getty Images		 Rapid Determination of 24 Synthetic and Natural Cannabinoids for LC–MS-MS Screening in Natural Products and Drug Inspection Applications
Marijuana, the common or slang term for cannabis in its herbal form, is one of the most widely used illicit drugs in the world. Synthetic cannabinoids have similar psychotropic effects to the natural ones and are rapidly being integrated by the illicit market. To deal with their expanding number and diversity, a targeted and untargeted liquid chromatography–tandem mass spectrometry (LC–MS-MS) screening method was developed, allowing for the simultaneous analysis of 24 synthetic and natural cannabinoids in 8 min for a wide variety of samples such as herbal smoking mixtures, incense sticks, serums, and cannabis plant material.
A Sensitive and Cost-Effective LC–MS-MS Method for Determination of 1α,25-Dihydroxyvita min D3 in Human Plasma
The biologically active form of vitamin D is an important analytical target in both research and clinical practice. However, quantification of 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) has been challenging because of the extremely low levels in circulation — in the low picograms-per-milliliter range. Here, we report a sensitive, time-efficient, and cost-effective liquid chromatography–tandem mass spectrometry (LC–MS-MS) method that combines the use of immunoaffinity extraction, 4-phenyl-1,2,4-triazole-3,5-dione (PTAD) derivatization, and methylamine adduction.
Genius 1050 Nitrogen Generator
The Genius 1050 Nitrogen Generator is Peak Scientific's proven solution for customers requiring nitrogen for their LCMS application. Genius 1050 utilises CMS technology to ensure the best purity & cleanest gas supply possible. Designed as a plug and play system this nitrogen gas generator is easy to install and produces gas on demand, meaning you do not need to worry about your lab running out of gas. Learn more
Development of a Fast LC–MS-MS Screen for Common Drugs of Abuse as an Alternative to Immunoassay Screening
Enzyme immunoassay (EIA) is a conventional drug screening technique, but it can be limited by cross-reactivity that can lead to high false positive rates.
An Investigation into the Use of Alternate Carrier Gases for the Determination of Volatile Organic Compounds in Water by GC–MS
This study focuses on United States Environmental Protection Agency (US EPA) Method 524.3 for volatile organic compounds (VOCs) in water using gas chromatography–mass spectrometry (GC–MS). The GC sample introduction and separation technique specified by the EPA is purge and trap and the detector is MS. This article discusses optimizing MS and chromatographic separation parameters when using alternative carrier gases.
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New Webcasts
Use of Novel Zirconia-Based Cleanup Sorbents for the Analysis of Contaminants in Fatty Food Samples
Tuesday, March 31, 2015
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Simplifying Carbohydrate Testing in Food and Beverages to Meet Food Quality and Labeling Requirements Using Ion Chromatography and Pulsed Amperometric Detection
Thursday, April 2, 2015
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Trouble-Free HPLC Analysis of Creams and Lotions
Tuesday, April 7, 2015
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The Diversity of UV/Vis/NIR Techniques for Nanomaterial Characterization
Wednesday, April 29, 2015
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