Effect of Binder Type on Dry Granulation and Tablet Compression Properties of a Model Formulation
Authors: Anshul Gupte, Michael Dehart, and Rahul Haware
Sponsored By: Metrics Contract Services
The purpose of the investigation was to compare the impact of roller compaction processing parameters and resulting tableting properties of roller compacted granules of specific binders.

Product Manufactured for Its Intended End Use
Author: Dora Meissner
Sponsored By: BioSpectra
The goal of manufacturing a product for its intended end use provides an additional level of security to the product.

Cleaning Validation for Pharmaceutical Manufacturing
Author: Malcolm McLaughlin
Sponsored By: Alconox
This whitepaper describes the why, what, and how to do cleaning validations in the pharmaceutical industry. This paper includes who should be involved, what type of data needs to be generated, limit determination, and equations needed for calculating needed values, as well as how to use the equations.

Comparison of HPC, PVP in Fluidized Bed Granulation
Authors: Kenji Sugisawa and Shinichiro Tsue
Sponsored By: Nippon Soda Co., Ltd.
We prepared both high and low drug load tablets of acetaminophen by fluidized bed granulation using a special low viscosity grade of HPC (HPC-SSL) and Polyvinylpyrrolidone (PVP K30). Tablet properties and drug release are compared.

Analysis of Cortisone Acetate Tablets by Nexera UC SFC
Sponsored By: Shimadzu
This application note presents an analysis of cortisone acetate tablets according to the USP monograph. The original normal phase method was transferred to an SFC method using both conventional and high-speed columns to determine whether the SFC method can meet criteria and reduce costs.

Improving Product Quality with Risk Assessment Tools
Author: Brenda Percy
Sponsored By: EtQ Inc.
With the product lifecycle moving so fast, many organizations may ask the question: How can we effectively measure quality? The answer is risk management. Learn the elements of risk management and how they help to identify, prevent, and mitigate risk throughout an organization.

Foaming via Melt Extrusion for Improving the Grindability of Extrudates and Dissolution Rate of Oral Dosages
Authors: G. Terife, C. Martin, C. G. Gogos, and N. Ioannidis
Sponsored By: Leistritz
Significant development efforts are occurring that utilize twin-screw extruder (TSE) technologies as part of unique foam extrusion systems for emerging bioplastics and pharmaceutical products.

Effect of Binder Type on Dry Granulation and Tablet Compression Properties of a Model Formulation
Authors: Anshul Gupte, Michael Dehart, and Rahul Haware
Sponsored By: Metrics Contract Services
The purpose of the investigation was to compare the impact of roller compaction processing parameters and resulting tableting properties of roller compacted granules of specific binders.