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Pharmaceutical Sciences, Manufacturing & Marketplace Report December 11, 2013


  From Cynthia Challener, PhD, Editor, Pharmaceutical Sciences, Manufacturing & Marketplace Report
In this issue, using evaporative light scattering to detect challenging, nonchromophoric sugars, peptides, and other biologics and a new Chinese hamster ovary cell line with knockouts for genes that lead to the incorporation of sugar groups in biotherapeutic proteins that are associated with immunogenic responses in patients. Plus examining formulation strategies for product lifecycle optimization, overcoming challenges in managing the cold chain, and advances in catalysis for API synthesis.
 
 

   
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Pharmaceutical Analysis
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Adam Gault/Getty Images

Evaporative Light Scattering Seeing Increased Use as Detector for Nonchromophoric Compounds

Difficult samples, including carbohydrates, triglycerides, lipids, phospolipids, underivatized fatty and amino acids, and modified peptides can be detected with high sensitivity and accuracy. Click Here to Read More

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Biological API Manufacturing
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Novel Host Cell Line Targets Potential Sources of Immunogenicity in Chinese Hamster Ovary Cells

A novel host cell line trait stacked with knockouts of the CMAH and GGTA1 gene sequences is designed to produce safer therapeutic proteins. Click Here to Read More

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Solid, Semisolid, and Specialty Dosage Forms
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Can Pharma Defy Gravity at the Patent Cliff?

Formulation strategies for product lifecycle optimization. Click Here to Read More

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Parenterals
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Challenges in Managing the Cold Chain

Industry experts discuss challenges in managing the cold chain. Click Here to Read More

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Chemical API Manufacturing
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Applying Catalysis to Optimize API Synthesis

Fine-chemical companies, contract manufacturers, and researchers advance chemocatalysis and biocatalysis. Click Here to Read More

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Other Recent Developments

New Solid Dose Technologies Highlighted at 2013 AAPS Annual Meeting & Expo
Excipients for lowering formulation costs and improving lipid-based formulations and the use of melt-spray-congeal microsphere sachet technology for targeted controlled release attract attention at the 2013 American Association of Pharmaceutical Scientists Annual Meeting.

Novartis’ US Influenza Cell-Culture Facility Recognized
For its use of innovative technology for the production of seasonal and pandemic influenza vaccines, the Novartis Holly Springs, North Carolina facility was the Overall Winner of the 2013 Facility of the Year Award issued by the International Society for Pharmaceutical Engineering (ISPE).

Maintaining and Verifying the Cold Chain
Tools and services provide thermal protection and prove cold-chain compliance.

Overcoming Challenges in Fluorine-Based Chemistry
Fluorinated molecules are important as pharmaceutical compounds. Recent advances involve selective and late-stage insertion of fluorine into small molecules.

Congress Revises Rules for Drug Compounding and Supply-Chain Security
Legislators agree on a limited bill affirming FDA authority over compounders while setting up a process for national drug tracking.

 
The Pharmaceutical Sciences, Manufacturing & Marketplace Report is a biweekly newsletter of Pharmaceutical Technology and BioPharm International, and an exclusive feature of the new Pharmaceutical Technology/BioPharm International Marketplace, an online community focused on products and services for drug development and manufacturing. The Pharmaceutical Sciences, Manufacturing & Marketplace Report provides insight in five main communities: solid, semisolid, and specialty dosage forms; parenterals; chemical API manufacturing; biological API manufacturing; and pharmaceutical analysis.  
 
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Perspectives from Cynthia Challener, PhD, editor of the Pharmaceutical Sciences, Manufacturing & Marketplace Report and industry members
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