Applying Catalysis to Optimize API Synthesis

Congress Revises Rules for Drug Compounding and Supply-Chain Security

Legislators agree on a limited bill affirming FDA authority over compounders while setting up a process for national drug tracking.

Site-Specific Conjugation of Cytotoxic Cytolysins Could Lead to Highly Effective Antibody-Drug Conjugates
Recent collaboration offers more heterogeneous, stable antibody drug conjugates of synthetic tubulin-binding agents shown to rapidly trigger cancer cell death.

Overcoming Challenges in Fluorine-Based Chemistry
Fluorinated molecules are important as pharmaceutical compounds. Recent advances involve selective and late-stage insertion of fluorine into small molecules.

Careful Process Mapping Can Significantly Reduce Product Losses in Fill-Finish Operations
Changes in the working procedures and disposable fluid flow paths resulted in a measurable decrease in product waste in a low-volume, high-value fill-finish line.

FDA Seeks Metrics to Define Drug Quality
Manufacturing standards are considered key to preventing drug recalls and shortages.

Tablet-Sticking Solutions
Screening methods and predictive models address tenacious tablet-sticking problems.