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Pharmaceutical Sciences, Manufacturing & Marketplace Report September 25, 2013
  From Cynthia Challener, PhD, Editor, Pharmaceutical Sciences, Manufacturing & Marketplace Report
In this issue, Pfizer applies a host-cell line that combines engineered glycosylation technology and enhanced gene-expression for antibody development.  Patheon advances single-use systems in fill–finish operations. GlaxoSmithKline develops flow-chemistry process to produce large quantities of a key Suzuki-Miyaura coupling reagent. Plus, the benefits of nondestructive headspace analysis and the importance of selecting the right granulation method.		  
 

   
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Biological API Manufacturing
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Pfizer Applies Integrated Technology for Cell-Line Development of Proprietary Antibodies

Pfizer advances its pipeline of antibody-based therapies using a host cell line that combines engineered glycosylation technology and enhanced gene expression. Click Here to Read More

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Parenterals
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Exploring Single-Use Systems for Fill–Finish Operations

The need to develop a final formulation process for a parenteral product sensitive to stainless-steel gave Patheon the opportunity to evaluate the potential of single-use technology in fill–finish operations. Click Here to Read More
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Chemical API Manufacturing
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GlaxoSmithKline Adopts Continuous Manufacturing for Preparation of Key Intermediate

Use of a continuous-flow reaction made it possible to scale up a highly exothermic reaction for the production of a key Suzuk–Miyarua coupling reagent. Click Here to Read More
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Pharmaceutical Analysis
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Adam Gault/Getty Images

Laser Headspace Analysis Advantageous for Monitoring Sterile Fill–Finish Operations

Measuring headspace gas composition and pressure allows sterile product manufacturers to simultaneously monitor important quality parameters rapidly and nondestructively.Click Here to Read More

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Solid, Semisolid, and Specialty Dosage Forms
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Granulation Method and Process Monitoring Matter

The characteristics of tableted solid dosage drugs often depend on the granulation process, so selecting the most appropriate granulation technique and monitoring the process are crucial. Click Here to Read More

Join our Solid, Semisolid, and Specialty Dosage Forms Linked-In Community
 
Other Recent Developments

Novartis Making Moves to Increase Biologics Manufacturing Capability
Novartis’ half-billion dollar investment in a new biologics production plant in Singapore represents a strategic commitment to its growing biologics portfolio.

Sigma-Aldrich, The Scripps Research Institute Translating Research into Commercial Applications
New partnership aims to eliminate months from the typical transition time required to move chemistry from the laboratory into commercial applications.

Avoiding Glass Delamination with Early Product/Container Testing
Determining the potential for glass delamination before a product goes to market is the best way to ensure product safety and prevent expensive recalls.

Mechanical Control with Foam Granulation Well-Suited for Pharmaceutical Manufacturing
Foam granulation is much easier to control under mechanical dispersion conditions, which is where most industrial processes operate.

Boehringer Ingelheim Pharmaceuticals Uses Two-Dimensional Ultra High-Pressure Liquid Chromatography in Process Development
2D-UHPLC enabled the simultaneous analysis of reaction conversion and enantiomeric excess in asymmetric hydrogenations.

 
The Pharmaceutical Sciences, Manufacturing & Marketplace Report is a biweekly newsletter of Pharmaceutical Technology and BioPharm International, and an exclusive feature of the new Pharmaceutical Technology/BioPharm International Marketplace, an online community focused on products and services for drug development and manufacturing. The Pharmaceutical Sciences, Manufacturing & Marketplace Report provides insight in five main communities: solid, semisolid, and specialty dosage forms; parenterals; chemical API manufacturing; biological API manufacturing; and pharmaceutical analysis.  
 
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Perspectives from Cynthia Challener, PhD, editor of the Pharmaceutical Sciences, Manufacturing & Marketplace Report and industry members
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