Application Note Alert

December 2011 Subscribe

Links to technical insights from sponsored Featured Application Notes on Chromatography Online.
Contact Editor
- Janet Kelsey

Featured Application Note:
Increasing LC-MS/MS Sample Throughput Using the Transcend TLX-2 System and Multiplexing for Research
Shane McDonnell, Thermo Fisher Scientific

Learn how to gain a significant increase – 393% – in sample throughput compared to standard HPLC methods in bioanalytical research laboratories. As a result of the shorter run times, the amount of relevant data to be stored decreased by 95%.

Sample Prep
Optimizing Gel Permeation Chromatography (GPC) using Economical, Quality Phenogel™ Columns
Michael McGinley, Phenomenex

Gel Permeation Chromatography (GPC) is principally used to separate polymers and organic molecules based on their size. Column, mobile phase, and temperature selection will be discussed to optimize GPC methods using Phenogel GPC/SEC columns.

Molecular Weight Determination of LMWH SEC/MALS vs. SEC/ UV-RI
Wyatt Technology

Low-molecular-weight heparins (LMWHs) are obtained by fractionation or depolymerization of natural heparins. They are defined as having a mass-average molecular weight of less than 8000 and for which at least 60% of the total weight has a molecular mass less than 8000.


LC/HPLC

A new solution to sensitivity & selectivity challenges
Yves Leblanc, Doina Caraiman, Mauro Aiello, Hesham Ghobarah, AB SCIEX

Whether facing the challenges of resolving a chromatographic interference, eliminating high baseline noise, or separating isomers, AB SCIEX SelexION Technology with the QTRAP® 5500 system offers a powerful new tool to help bioanalytical scientists solve tough selectivity challenges.

Food Safety Analysis: LC/MS/MS Applications Using New Kinetex® Core-Shell Technology Columns
Philip J. Koerner, Terrell Matthews, and Jeff Layne, Phenomenex

The availability of alternative bonded phases based on the ultra-high efficiency Kinetex core-shell technology provides orthogonal selectivity that is shown to be useful for the separation challenges presented in food safety analysis.

Analysis of biodiesel fuel using UPLC/Xevo G2 QTof
Melvin Gay, Jane Lee, Evelyn Goh, Waters Corporation

Separation and identification of methyl esters and glyceride classes. 15-minute method provides information for the monitoring of glyceride classes during biodiesel production stages.


sampleprep
One-Step Extraction and Concentration for Identifying Pharmaceuticals and Personal Care Products in Water, Biosolids and Solids
Tom Hall, FMS, Inc.

The scope of human exposure to Pharmaceuticals and Personal Care Products (PPCPs) from the environment is complicated and increased monitoring is occurring to determine the effect on humans of long-term, low-level exposure to PPCPs. Due to their persistent nature and toxicity,monitoring water sources for PPCPs is a growing priority for both government agencies and consumers. The following procedure outlines the fully automated, sample-to-vial extraction and concentration of water matrices for the detection of these compounds in one rapid and efficient process.

GC
High Efficiency, Quantitative Dioxins Screening at the Level of Interest in Feed and Food using Advanced GC-MS/MS
Paul Silcock, Dirk Krumwiede, Inge de Dobbeleer, Hans-Joachim Huebschmann, Thermo Fisher Scientific

Current European Union regulations permit the use of GC-MS/MS and bioassay techniques for screening dioxins and dioxin-like PCBs at the level of interest in feed and food samples. GC coupled with triple quadrupole MS is particularly suitable screening technique as isotope dilution is retained as well as the high selectivity of the MS/MS experiment. This application note describes the use of a GC-MS/MS as applied to high efficiency screening of PCDDs/PCDFs in feed and food samples. at the levels of interest and the level of confirmatory analysis using GC-HRMS.

Miscellaneous
Separation of Peptides from Enzymatic Digestion
Dai Zhenyu, Dionex Products, now sold under the Thermo Scientific brand

This application note describes a comparative study of peptide separations on Acclaim columns from Thermo Fisher Scientific Inc.

To advertise or have an application note inserted, contact:

Lee Noyes
+44 1244 629315 | Email

Lindsay Jones
+44 1244 629316 | Email

 



You are subscribed to %%list.name%% as %%emailaddr%%. Click here to unsubscribe or edit your member profile.

To ensure delivery to your Inbox, please add %%email.list%% to your address book. If you need help doing this, click here.

Advanstar Communications provides certain customer contact data (such as customers' names, addresses, phone numbers and e-mail addresses) to third parties who wish to promote relevant products, services and other opportunities which may be of interest to you. If you do not want Advanstar Communications to make your contact information available to third parties for marketing purposes, simply call (toll free) 1-866-529-2922 at any time, or fax us at 1-218-740-6417. Outside the U.S., please phone 1-218-740-6395. Contact us by mail at Advanstar Communications Inc., Bridgegate Pavilion, 4A Chester Business Park, Wrexham Road, Chester, CH4 9QH, UK.