In our December issue:
COLUMNS:
COLUMN Watch
Drawing A Better Map: Recent Advances in Protein Digestion and Peptide Mapping
This month's "Column Watch" describes advances in "bottom-up" analysis of monoclonal antibodies while highlighting the role and importance column chemistry still plays in developing highly selective HPLC methods for peptides. Read more >>
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LC TROUBLESHOOTING
Letting the Chromatograph Talk, Part 1 — Looking for Clues in Unexpected Places
Is a UV detector signal good for anything if the analyst is using a mass spectrometer? Read more >>
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THE ESSENTIALS
How It Works: UV Detection for HPLC
The fundamental principles of UV detection are presented.
Read more >>
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FEATURES:
Lloyd R. Snyder (1931-2018): A Personal Tribute
Lloyd Snyder was one the "founding fathers" of high performance liquid chromatography (HPLC). He was one of the most widely cited chromatographers with many important contributions to the field of separation science. Read more >>
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Analysis Focus: GC: Moving Gas Chromatography Forward
Ronda Gras from Dow Chemicals spoke to LCGC Europe about her innovative work in the field of gas chromatography (GC), including a project to develop a hyphenated GC technique with simultaneous detection using ultraviolet spectroscopy, flame ionization, and mass spectrometry. Read more >>
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PEER-REVIEWED ARTICLES:
Recent Advances in Comprehensive Chromatographic Analysis of Emerging Drugs
To address the challenges of analyzing new illicit drugs, emerging techniques, such as ultrahigh performance supercritical fluid chromatography (UHPSFC) with mass spectrometry (MS) and ultraviolet (UV) detection, and gas chromatography (GC) with vacuum ultraviolet (VUV) detection, may be needed, particularly for distinguishing positional isomers and diastereomers. Read more >>
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Molecular Imprinting for Sample Preparation
Molecularly imprinted polymers (MIPs) can replace conventional sorbent materials in sample preparation techniques such as solid-phase extraction (SPE), solid-phase microextraction (SMPE), and matrix solid-phase dispersion (MSPD), offering increased selectivity over the target analytes. Read more >>
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