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Cover Story
The LCGC Europe/HTC-15 Innovation Award was launched to celebrate the work of scientists who are innovatively evolving the field of hyphenated techniques. read more
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A Raptor EtG/EtS column is your solution! The Raptor EtG/EtS column consistently retains and resolves EtG and EtS from matrix interferences, providing accurate, reliable results injection after injection. Highly stable performance and long column lifetime make this column ideal for alcohol consumption monitoring by high-throughput labs. Save time and increase certainty with Restek's definitive EtG/EtS method, a Raptor EtG/EtS column, and our quality reference standards!  Learn more
The LCGC BLOG
I hear the words "struggling for sensitivity" so often when speaking to folks using LC–MS for bioanalysis, environmental analysis, metabolomics, proteomics, and a host of other applications where target analytes are present at low concentrations in complex matrices. We spend fortunes on MS/MS instruments to increase specificity of detection in order to improve sensitivity. Some of us go to great lengths to optimize sample extraction and HPLC conditions in order to minimize matrix suppression effects and improve specificity and hence sensitivity.
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New HIC-MS chemistries for Top Down proteomics of intact proteins. Conventional HIC materials, may not adequately retain proteins using ammonium acetate buffers. RPC may be too hydrophobic to not denature or precipitate proteins. The new PolyPENTYL A™ chemistry from PolyLC™ addresses this. Characterize  large protein variants by HIC-MS on your MS today! The Nest Group, Inc. - “Not Just Columns ... Answers!”
FEATURE
Monitoring lipid oxidation during the shelf life of lipid-containing food emulsions, such as mayonnaise, is challenging. It is, however, essential for the development of improved, consumer-preferred products. A method based on normal-phase liquid chromatography with atmospheric pressure photo ionization-mass spectrometry (LC–APPI-MS) was developed for this purpose.
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LCGC TV
Antibody–drug conjugates (ADCs) are very important cytotoxic drugs. Alain Beck from the Center of Immunology Pierre Fabre discusses the development of a two-dimensional liquid chromatography (2D-LC) method for quantifying free drug species in ADC samples, and the importance of quantifying free drug species. read more
Comparability assessments always have two basic questions: Is the new material the same or is it different? If it's different, what do the differences mean for patients? Reed Harris from Genentech discusses if the approach to comparability assessments needs to vary depending on whether one is talking about a commercial product or one still in development. read more
NEWS
Researchers from the Japanese Institute of Neuroscience have identified differences in the low-molecular-weight metabolite profiles of the brains of schizophrenia patients using CE–TOF-MS.
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Application Note
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The Agilent 1260 Infinity II Analytical SFC system performed automated method development, screening four chiral columns under different conditions.
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FEATURED PRODUCTs
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This is our latest DEGASi®. It can be equipped for a wide range of application. DEGASi® PLUS is a further development of degassers such as DEGASi®Classic, DEGASi®GPC, DEGASi®Micro & DEGASi®Semi-Prep.
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Mobile Control Chrom is an easy-to-use software for Windows 10 based tablets and PCs, which allows users to monitor and change settings of KNAUER AZURA HPLC devices plus data acquisition for one instrument.  / View demo. / |
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Clarus® 590 and 690 systems provide operational simplicity and flexibility. With powerful headspace sampling capabilities they are ideal for the residual solvents inert and active ingredients analysis in pharmaceuticals.
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PharmaFluidics’ game-changing chip-based chromatography column for nano-LC, lets you detect more molecules in tiny, complex biological samples. High resolution separations are obtained, perfect for lipidomic, metabolomic and peptide profiling.
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Porvair Sciences 96-well Supported Liquid Extraction (SLE) microplate enables high recovery extraction of analytes from biological fluids. High analyte recovery, free of proteins and phospholipids, is now possible without need for offline steps.
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ACE HILIC Method Development Kits provide an unrivalled screening platform for the development of successful and robust HILIC methods, grouping together three alternative HILIC phases for the cost of just one column.
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The µDAWN™ is the world's first multi-angle light scattering (MALS) detector that can be coupled to any UHPLC system in order to determine absolute molecular weights and sizes of polymers, peptides, and proteins.
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Coated and immobilised CHIRAL ART polysaccharide columns by YMC offer wide selectivity range (NP, RP, SFC), high stability and attractive pricing. 3-5-10-20 µm are available for analytical and prep scale.
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