In our February issue:
COLUMNS
HISTORY OF CHROMATOGRAPHY
Leading Light: Pavel Jandera
Pavel Jandera spoke to Frantisek Foret about building his own liquid chromatograph, the birth of “modern” high performance liquid chromatography (HPLC), the importance of exploring (and understanding) earlier research papers, current trends in contemporary chromatography, and offers inspiring advice for aspiring chromatographers. |
LC TROUBLESHOOTING
Chemical Attack
The silica-based packing in reversed-phase columns is not inert. Here we consider what happens when the mobile phase pH is too high or too low. |
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COLUMN WATCH
Fluorinated Stationary Phase Interaction Mechanisms
In this latest instalment of “Column Watch”, the differences between alkyl phases and PFP phases are discussed in terms of fundamental interactions. The origin of the interactions is also interpreted to better understand how analysts can use and control them to develop effective and rugged analytical methods. |
QUESTIONS OF QUALITY
Do You Understand CSV?
Data integrity issues are changing the way that we should be undertaking computerized system validation (CSV) of our chromatography data systems (CDSs). Do you understand what is required in the brave new world of CSV? |
THE ESSENTIALS
Troubleshooting Sample Preparation
Some tips on effective sample preparation troubleshooting. |
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PEER-REVIEWED ARTICLE
The Rise of HILIC
This review presents an overview of the most recent technical improvements and applications of HILIC analysis in the field of untargeted clinical metabolomics and discusses important practical considerations, including the selection of the optimal column chemistry, appropriate eluents, sample preparation, and data analysis.
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