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27 February 2014
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| In this Issue |
LCGC TV: Characterizing protein biopharmaceuticals with LC–MS
By 2020, more than 50% of approved drugs are expected to be protein biopharmaceuticals. In two new videos from LCGC TV, Koen Sandra from the Research Institute for Chromatography in Belgium discusses the challenges of characterizing protein biopharmaceuticals and why LC–MS is now indispensable for characterization. More... |
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Principle Component Analysis with LC–MS enhances Natural Drug Discovery Process
Scientists in Malaysia have collaborated to develop a useful metabolomics approach that could help analysts to overcome the bottleneck in natural product drug discovery. The team applied liquid chromatography–mass spectrometry (LC–MS) coupled with principle component analysis (PCA) to screen more than 4000 natural extracts for novel photosensitizer drugs. More... |
| ACE UltraCore Solid-core LC Columns |
ACE UltraCore is a new range of ultra-inert, solid-core (superficially porous) particle UHPLC/HPLC columns from Advanced Chromatography Technologies Limited. The monodisperse particle distribution of these phases combines high efficiency and performance, with a low column back pressure, to deliver exceptional chromatography. Two complementary phases, SuperC18 and SuperPhenylHexyl, both offer excellent peak shape and superb phase stability across an extended pH range of 1.5 to 11.0.  Learn more.
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LC–MS–MS Method Developed to Detect Synthetic Opioid
US scientists have developed a new method for an emerging synthetic opioid associated with increased health risks and deaths. Scientists from the Center for Drug Detection and Response, a biomedical research consortium in the USA, have developed a method using liquid chromatography coupled to tandem mass spectrometry (LC–MS–MS) for the detection of acetyl fentanyl in human urine. More... |
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Current features |
Georges Guiochon: Separation Science Innovator
Professor Georges Guiochon spoke to Fabrice Gritti about his pioneering contributions to the field of separation science. More... |
ISC 2014: The Sound of Chromatography
The hills will be alive with the sound of chromatography when the 30th International Symposium on Chromatography (ISC 2014) takes place from 14–18 September 2014 in Salzburg, Austria. Here the conference organizers talk through what to expect at the event. More... |
| Application Notes |
| Waters Corporation |
Xevo G2-S QTof and TransOmics
Ian Edwards, Jayne Kirk, and Joanne Williams, Waters Corporation
The development and application of flexible informatics solutions that are capable of integrating the results from multiple discovery areas is of key importance. This study describes a multi-omics solution for the large-scale analysis of MS data from metabolomics and proteomics data sets. Learn more.
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| Beckman Coulter Life Sciences |
Improve CE-SDS Results with Automated Sample Preparation
Michael Kowalski, Clarence Lew, James A. Thorn, and Mehul P. Vora, Beckman Coulter Life Sciences
This application note presents an automated preparation method for the analysis of IgG protein samples by CE-SDS. The method improves results, reduces sample preparation variability, and samples show reproducible peak areas and migration times. Learn more.
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| Multimedia |
| The CHROMacademy Essential Guide Webcast: Top 10 Features of a Successful Chromatography Data System |
| Sample Preparation Method Development for Unconventional Matrices |
| The Use of Solid Core Technology in the Pharmaceutical Environment |
Need GC Troubleshooting Help?
 CHROMacademy announces the launch of the interactive GC Troubleshooter, sponsored by Thermo Scientific.
Building on the success of our ground breaking HPLC Troubleshooter, we are excited to announce the GC version. In 3 simple steps you will overcome your instrument, separation and quantitation issues. It’s completely free - so if you haven't tried our troubleshooter before you're in for a surprise!  Click Here |
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| The Column |
 The Global E-zine for Separation Scientists
The global edition of The Column is delivered twice monthly with a screen-optimized format designed to improve readability. Covering topical issues, application-based articles, market reports, tips and tricks, opinion pieces and interviews, The Column is a great information resource helping readers achieve better day-to-day working practices.
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Contact Us
Click here to contact Kate Mosford, managing editor.
Click here to contact Mike Tessalone, group publisher.
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