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Featured Application Note:
Method Development for Enantiomers
Angelika Gratzfeld-Huesgen, Agilent Technologies
This application note demonstrates the method development for chiral compounds, using the Agilent 1200 Infinity Series Method Development Solution with the Agilent Method Scouting Wizard. Download the app note |
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High pH Stability of a Core-Shell Particle
Mark Woodruff and Ken Butchart, Fortis Technologies, Ltd
In this application note we show how the use of core-shell particles has been extended. Up until now core-shells have suffered from a relatively narrow pH range. Now with the launch of SpeedCore pH Plus the pH range has been expanded from pH 1-12, meaning no buffer or pH limitations. Download the app note |
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Combining Mass and UV Spectral Data with Empower 3 Software to Streamline Peak Tracking and Coelution Detection
Paula Hong and Patricia R McConville, Waters Corporation
Methods development using a single detection technique can be challenging. UV spectral data can assist in peak purity and identification. However it is difficult to perform peak tracking in the presence of coelutions. For simplified methods development, a chromatographic system using both UV and mass detection and a streamlined software platform can be combined to evaluate peak purity and assist in the identification of coelutions in a single run. Download the app note |
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Low-Molecular-Weight Heparins
Wyatt Technology
Size-exclusion chromatography (SEC) has been the most common way of measuring the molecular weight and molecular weight distributions of LMWHs by using the two most common detection technologies: ultraviolet (UV) coupled with refractive index (RI) detection. However, these detectors embody a relative method in order to determine molecular weights, requiring calibration standards. Download the app note |
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GPC Characterization of Nylon Using Formic Acid for Reduced Cost per Analysis
Malvern Instruments
GPC/SEC can be used to characterize commodity or bulk manufactured polymers. Here, we describe how the use of formic acid instead of hexafluoroisopropanol (HFIP) as the dissolution solvent or mobile phase can lead to improvements in both cost per analysis and health and safety. Download the app note |
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SPE and Analysis Of Organochlorine Pesticides and Inline Cleanup from Water
Philip Bassignani, FMS,Inc.
In water samples, OCPs are monitored by the U.S. Environmental Protection Agency by various methods including methods EPA 508, EPA 608, and EPA 8081. The use of solid phase extraction (SPE) can rapidly increase both extraction efficiency and reduce lab solvent usage. By implementing the FMS TurboTrace® ABN system with its dual cartridge functionality, an in-line Florisil cartridge can be added to perform automated extract clean-up during the elution step. Download the app note |
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Bio-monitoring of Phthalate Metabolites in Urine
Roy Gerona and Frank Kero, Biotage AB , Sweden
This application note describes the extraction of nine phthalate metabolites from human urine using ISOLUTE® ENV+ solid-phase extraction columns. Phthalates are ubiquitous in our everyday lives and present threats of low level exposure through inhalation or ingestion. Download the app note |
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Quantitative Analysis of Benzodiazepines in Whole Blood
Xiaoyan Wang and Jody Searfoss, UCT, Inc.
Benzodiazepines are psychoactive drugs prescribed for treating a variety of ailments. They are deemed safe and effective for short term use. Frequent use may lead to dependence and abuse. Because of this attribute toxicology laboratories are interested in monitoring these compounds in biological samples. This application utilizes a QuEChERS extraction technique for the quantitative analysis of benzodiazepines in whole blood. Download the app note |
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