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Featured Application Note:
Determination of Basic and Acidic Pesticides Using Online SPE–LC–MS
Edgar Naegele, Agilent Technologies
This application note demonstrates the determination of basic and acidic pesticides at sub-ppt levels in drinking water using the Agilent 1200 Infinity Series Online SPE Solution with an Agilent 6460 Triple Quadrupole Mass Spectrometer System.
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Compass PathwayScreener™ – Metabolic Pathway Directed Targeted Metabolomics
Dr. Heiko Neuweger, Dr. Verena Tellstrom, and Dr. Aiko Barsch, Bruker Daltonics
Metabolic pathways enable biologists to structure and link biochemical processes, and are key to the interpretation of targeted metabolomics experiments. However, the growing number of detectable and identifiable substances increases the need for efficient data analysis and interpretation. Given a start compound, the Compass PathwayScreener interrogates a pathway database to automatically generate a list of biochemically relevant compounds that can be searched for in complex MS data sets. Read More |
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Extraction and Analysis of Nicotine, Cotinine, and Anabasine from Urine using SPE and GC–MS
Jeff Hackett, UCT, LLC
Nicotine is a highly addictive stimulant drug. In this analytical procedure, nicotine, cotinine, and anabasine were extracted from urine via solid-phase extraction and analyzed by GC–MS. The confirmation of anabasine in this procedure distinguishes regular tobacco use from e-cigarette, nicotine gum, or nicotine patch users. E-cigarettes, patches, and gums contain only nicotine (metabolizing to cotinine) and not the tobacco alkaloid anabasine. Read More |
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Total Extractable Fat from Food and Feed Matrices Using Pressurized Liquid Extraction
Philip Bassignani, FMS,Inc.
The extraction of total fat from samples is widely used in both the food and feed industries as well as for the analytical analysis of priority organic pollutants (POPs). For several compounds of concern like PCB and PBDE congeners, results are often expressed in amount for gram of lipid. In food and feed products, regulating fat content is essential in maintaining quality control. The following note details the usage of the FMS, Inc PLE for the extraction of total fat from a variety of sample matrices. Read More |
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Determination of Parabens in Body Wash using Solid-Supported Liquid-Liquid Extraction
Devon C. Zimmerman, Henry F. Rossi III, Daniel W. Keating, Jacqueline Rizzo, and Karyn M. Usher, Agilent Technologies
This application note describes the extraction and analysis of four parabens from an infant shampoo/body wash using solid-supported liquid-liquid extraction (SLE) cartridges and an Agilent 1200 HPLC system. Read More |
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Extraction of Aflatoxin M1 From Infant Formula Using ISOLUTE® Myco prior to LC–MS–MS Analysis
Adam Senior, Biotage AB, Sweden
This application note describes a solid-phase extraction (SPE) protocol for the extraction of aflatoxin M1(AM1) internally standardized with aflatoxin B2 (AB2) from infant formula using ISOLUTE® Myco SPE columns with LC–MS–MS analysis. The method described in this application note achieves high recoveries of aflatoxin M1 from infant formula with % RSDs and LOQs that all meet the requirements set in European regulations. Read More |
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Determination of Brominated Vegetable Oil in Soft Drinks by UPC2/MS
Jinchuan Yang, Waters Corporation
This application note demonstrates a rapid and simple analysis of brominated vegetable oil (BVO) in soft drinks and beverages using convergence chromatography and tandem mass spectrometry. BVO was extracted and analyzed directly without any derivatization and the chromatography total run time was 9 min. Read More |
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