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Better Gel Filtration: A New Look at Method Development Parameters
Michael McGinley, Ismail Rustamov, Michael Klein, and colleagues, Phenomenex
In addition to higher efficiency, Yarra columns demonstrate significantly higher inertness to ionic interactions. Performing method development through mobile phase composition using Yarra columns is discussed. Read More |
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Achieving Improved Intact IgG Separations Using Wide Pore Core-Shell HPLC/UHPLC Columns
Michael McGinley, Deborah Jarrett, and Jeff Layne, Phenomenex
The high permeability of the Aeris core-shell particle combined with low hydrophobicity and inert surface results in high recoveries and improved peak shape for even the most hydrophobic proteins. Read More |
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Using Longer Core-Shell HPLC/UHPLC Columns for Improved Peptide Mapping
Michael McGinley, Deborah Jarrett, and Jeff Layne, Phenomenex
A 3.6 µm 100 Å HPLC/UHPLC core-shell particle was specifically engineered to improve separations of peptide and peptide mapping applications by maximizing resolution while maintaining speed. Read More |
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Improving Intact Biogeneric Protein Separations with Wide Pore Core-Shell Columns
Michael McGinley, Deborah Jarrett, and Jeff Layne, Phenomenex
Improved resolution acquired with widepore core-shell technology is especially useful for refolding, impurity, and post- translational modification assays on intact biogeneric proteins where very slight differences between intact and modified proteins elute closely on reversed phase columns. Read More |
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Relevant Parameters in Developing Protein Aggregation Methods Using GFC/SEC Columns
Michael McGinley, Ying Wang, and Ismail Rustamov, Phenomenex
As compared to other GFC columns, Yarra columns demonstrate significantly higher inertness to ionic interactions. Such chemical characteristics sometimes require changes to operating parameters, which are discussed in the method development for protein aggregation analysis. Read More |
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Improving Intact IgG Separations with Wide Pore Core-Shell HPLC/UHPLC Columns
Michael McGinley, Jeff Layne, and colleagues, Phenomenex
A new widepore core-shell HPLC/UHPLC column is specifically designed to improve protein separations. A completely different particle was developed that takes into account the slower diffusion of proteins into porous particles. Read More |
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