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Macrolides in Honey Using Agilent Bond Elut Plexa SPE, Poroshell 120, and LC–Tandem MS
Chen-Hao (Andy) Zhai and Rong-jie Fu, Agilent Technologies
This application note describes a method for the simultaneous determination of macrolide residues in honey. The analytes were extracted and cleaned with Agilent Bond Elut Plexa (SPE), separated on an Agilent Poroshell 120 HPLC column and quantified by liquid chromatography–tandem mass spectrometry (LC–MS-MS). The method provided trace level limit of detection for all macrolides in honey. Read More |
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Sample Prep for Trace Analysis of Adulterants in Erectile Dysfunction Dietary Supplements
Derick Lucas, Agilent Technologies
Detecting and measuring analytes of interest in dietary supplement matrices presents many challenges due to their chemical complexity, and includes the elimination of chemical interferences, reduction in instrument contamination, and accounting for matrix effects. These issues are increasingly relevant for ED supplements that can include a single plant extract or a concoction of ingredients including Muira Puama, Korean ginseng, cinnamon, Ginkgo biloba, cordyceps, and so forth. This application note demonstrates the importance of sample cleanup for trace level analysis of ED dietary supplements. Read More |
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Analysis of Pesticide Residues in Chicken Using Agilent BondElut QuEChERS and LC–MS-MS
Chen-Hao (Andy) Zhai and Rong-jie Fu, Agilent Technologies
This application note describes the use of a quick, easy, cheap, effective, rugged, and safe (QuEChERS) AOAC sample preparation approach for the extraction and cleanup of 12 pesticide residues representing various pesticide classes in chicken. The spiking levels for the recovery experiments were 10 and 50 ng/g and the mean recoveries ranged between 76% and 107%, with RSD below 10%. Read More |
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Analysis of Fruit and Vegetable Pesticides by GC–MS-MS Using Agilent Inert Flow Path
Limian Zhao and Mike Szelewski, Agilent Technologies
The Agilent Inert Flow Path (IFP) solution was evaluated and validated thoroughly for the analysis of trace pesticides in various fruits and vegetables by GC–MS-MS. The results demonstrate excellent surface inertness for the entire GC flowpath and reduced negative impacts on the target analytes caused by surface active sites. Comparison results are also included. Read More |
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Optimizing Sample Preparation for LC–MS-MS of Pesticide Residues in Herbal Teas
Derick Lucas, Agilent Technologies
A QuEChERS protocol was optimized using Agilent Bond Elut QuEChERS premeasured kits to provide fast and easy method development. The method gives adequate cleanup for the highly pigmented samples and delivers high recovery and reproducibility for the majority of pesticides, without significant retention of planar pesticides. Read More |
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Analysis of Pesticide Residues in Chicken Muscle with QuEChERS and Triple Quadrupole GC
Chen-Hao (Andy) Zhai and Yun Zou, Agilent Technologies
A GC–MS-MS multiple reaction monitoring method was developed on the Agilent 7890A GC and an Agilent 7000B GC Triple Quadrupole GC–MS System for 54 pesticide residues in chicken. Sample preparation followed the QuEChERS AOAC extraction method with two different dispersive cleanup techniques. The quantification limit of most compounds can be down to 5 ng/g (5 ppb). Read More |
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A QuEChERS Strategy for Juice Concentrates with Unknown Properties Analyzed by GC–MS-MS
Mike Chang, Agilent Technologies
Juice concentrates with unknown properties can be very challenging during modification of the QuEChERS protocol when there is a need to accommodate variables such as the concentration factor, and whether or not the samples contain peel. In this application note, method development for sample preparation using QuEChERS is discussed for orange and lemon juice concentrates, followed by analysis with GC–MS-MS. Read More |
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