ARTICLES

Developments in the Preparation of Organic Polymer Monoliths for the Separation of Small Molecules
Jiri Urban and Pavel Jandera
This article describes recent developments in the preparation of organic polymer monoliths suitable for the separation of small molecules in the isocratic mode and identifies the main factors affecting column efficiency.

Application of Pyrolysis–Gas Chromatography–Mass Spectrometry for the Identification of Polymeric Materials
Peter Kusch, Gerd Knapp, Wolfgang Fink, Dorothee Schroeder-Obst, Volker Obst, and Johannes Steinhaus
The pyrolysis–GC–MS method enables direct analysis of solid or liquid polymers without sample pretreatment, as illustrated here for various materials, including a dental filling material and a car wrapping foil.

ADVERTISEMENT Waters CORTECS 2.7 µm Solid-Core Particle Columns have arrived! CORTECS® 2.7 µm Columns are designed to heighten performance of existing LC system and maximize efficiency at HPLC-optimized backpressures. This pressure advantage without an efficiency trade off, provides the flexibility to run methods using longer column lengths for improved resolution or higher flow rates to speed analysis and increase throughput.Learn more

COLUMNS

Sample Preparation Perspectives
Exploring the Possibilities of High-Throughput Sample Preparation
Douglas Raynie
Sample preparation has often been viewed as the bottleneck in analytical procedures. Surveys have shown that time is typically the most frequent problem area for sample preparation procedures and that analysts can easily spend a majority of the total analysis time on sample preparation. While newly developed extraction techniques address time, modern chromatography advances are also moving toward faster separations. Based on these considerations, what is high-throughput sample preparation? Do modern extraction methods adequately address the issue of time? How can we address the analytical need for speed?.

LC Troubleshooting
UV Detector Problems
John W. Dolan
UV detectors are the most common LC detector, and perhaps the most reliable ones. But they are not without problems.

Perspectives in Modern HPLC
Superficially Porous Particles: Perspectives, Practices, and Trends
Szabolcs Fekete, Davy Guillarme, and Michael W. Dong
The current trend in liquid chromatography tends toward the achievement of higher efficiency and shorter analysis time. Several innovative technologies have been commercialized to meet these requirements, and among them, columns packed with superficially porous particles (SPP) have created considerable excitement over the last few years. Indeed, this column technology manifests the advantages of fully porous material (loading capacity, retention) and some beneficial properties of nonporous particles (kinetic performance). This review provides an updated overview of the theory behind the success of SPP technology, trends, benefits, and limitations. It also summarizes the latest developments of sub-2-μm SPP and instrumental constraints associated with its use. Finally, it describes several applications to illustrate the performance achievable and the universal applicability of these newly engineered particles.

DEPARTMENTS:
Products
Events

The June issue of LCGC Europe will also be accompanied by an LC Troubleshooting wall chart.

ADVERTISEMENT Unleash the Power of Your Laboratory's Instrumentation Waters new CORTECS® 2.7 µm Solid-Core Particle Columns are designed to heighten performance of existing LC system. These column are available in both traditional HILIC and C18 options, but it is the unique C18+ column that offers unique selectivity, exceptional peak shape and loading capacity without the need for ion-pair reagents, and improved signal-to-noise performance in LC-MS applications.Watch this short video to learn more.