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31 May 2013 |
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Things You Should Know About Your HPLC Column
The physical characteristics of silica-based HPLC columns can affect the performance of the separation almost as much as the bonded phase. This instalment of the LCGC Blog re-visits some of the lesser-known facts relating to silica particles used for chromatography. More... |
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Safe and Sustainable Water Resources: Q&A Interview
The National University of Singapore Environmental Institute (NERI), Singapore Centre on Environmental Life Sciences Engineering (SCELSE), and Thermo Fisher Scientific are collaborating on a project to monitor and improve water quality in Singapore. LCGC spoke to the scientists involved to find out more about the project. More... |
| CHROMacademy |
 5 Years Free Access to CHROMacademy
To show our commitment to learning, we have decided to offer all university students and staff free access to CHROMacademy. You are the future leaders and innovators of the scientific community, and by offering free access to CHROMacademy we hope to help you realize your potential. This has been made possible by Agilent Technologies- the world’s premiere measurement company.
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| Current features |
Advances in Supercritical Fluid Chromatography for the Analysis of Chiral and Achiral Pharmaceuticals
A revival of supercritical fluid chromatography (SFC) has been observed recently. SFC has repeatedly enabled fast and efficient separations, and in some cases has even outperformed high performance liquid chromatography (HPLC). This article provides an overview of the most recent advances in the field of chiral and achiral separations in SFC. This involves research focused on the most critical parameters in SFC separations, but also on practical issues such as the serial coupling of columns. The recent evolution from classic SFC to ultrahigh-performance supercritical fluid chromatography (UPSFC) is also discussed. More... |
Automated MAb Workflow: From Harvest Cell Culture to Intact Mass Analysis of Variants
Recombinant monoclonal antibodies (MAbs) are a growing class of therapeutic molecules. Early in the development of MAbs, a large number of harvest cell culture (HCC) samples must be screened for immunoglobulin G (IgG) titer, aggregations, and charge variants. This study describes a two-dimensional (2D) high performance liquid chromatography (HPLC) workflow for affinity, size-exclusion, and ion-exchange analysis. More... |
| Teledyne Tekmar |
 Validation of Volatile Organic Compound by USEPA Method 8260C
In order to determine the concentration of volatile organic compounds (VOCs) in water and soil matrices the USEPA developed Method 8260C1 in conjunction with preparative Methods 50302 and 50353. Water and soil sample analysis were analyzed in this study. A working linear calibration curve and Method Detection Limits (MDLs) will be demonstrated for various target compounds from the approved list. The water study used a 5mL sample volume, while the soil study utilized a 5 gram mass under in vial purge conditions. Read more |
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| Multimedia |
Tips and Tricks on Screening and Confirmatory Methods for Residues and Contaminants in Foods
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| Editors' Series: A Generic HPLC–UV Platform Method for Cleaning Verification |
| The CHROMacademy Essential Guide: GC–MS/MS Analysis – What you need to know!
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Need LC Troubleshooting Help?
CHROMacademy has developed the HPLC Troubleshooter with busy chromatographers in mind. Sponsored by Thermo Scientific, in 3 simple steps you will overcome your instrument, separation and quantitation issues. It’s completely free - so if you haven't tried our troubleshooter before you're in for a surprise! http://bit.ly/LC_Troubleshooting |
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| The Column |
 The Global E-zine for Separation Scientists
The global edition of The Column is delivered twice monthly with a screen-optimized format designed to improve readability. Covering topical issues, application-based articles, market reports, tips and tricks, opinion pieces and interviews, The Column is a great information resource helping readers achieve better day-to-day working practices.
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