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Evaluating Protein Glycosylation in Limited-Quantity Samples by HPAE-PAD
Deanna Hurum, Lipika Basumallick, and Jeffrey Rohrer, Thermo Fisher Scientific, Inc.
Changes in protein glycosylation are frequently studied in cancer research to identify potential biomarkers. Factors investigated include differences in overall oligosaccharide (glycan) content, monosaccharide content changes, differences in sialylation amount and sialylation linkages, the degree of fucosylation, and differences in glycan branching. Read More |
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Determination of Methylamine in Drug Products
Thunyarat Phesatcha, Suparerk Tukkeeree, and Jeff Rohrer, Thermo Fisher Scientific, Inc.
Methylamine or monomethylamine (MMA) is widely used in different stages of the preparation of various drug substances; therefore it may be retained in the drug substance. Although there is little information concerning its effect on human or animal health, its median lethal dose in a mouse is reported to be 2.5 g/kg. Read More |
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Determination of Morpholine in Linezolid by Ion Chromatography
Lillian Chen, Brian De Borba, and Jeffrey Rohrer, Thermo Fisher Scientific, Inc.
Morpholine is a six-membered heterocyclic compound that features amine and ether functionalities, making it a commonly used compound in organic synthesis. Substituted morpholine derivatives are the core of various natural products and biologically active compounds. Thus, morpholine has been used in the production of many types of therapeutic agents such as antibacterials, antimicrobials, anticancers, antitussives, antimalarials, anticonvulsants, and analgesics. Read More |
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Determination of Dissolved Manganese in Lithium/Manganese Oxide Battery Electrolyte
Chanita Chantarasukon, Suparerk Tukkeeree, and Jeff Rohrer, Thermo Fisher Scientific, Inc.
Lithium-ion batteries are widely used in products such as portable consumer electronic devices and electric vehicles. Many different materials are used to make the cathode in lithium batteries, including those that are manganese-, cobalt-, and nickel-based. Lithium-ion batteries that are manganese-based are more environmentally friendly, have a good safety record, and can be made at a lower cost; however, they have a shorter lifetime than other types of lithium-ion batteries. Read More |
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Determination of Chloride and Sulfate in Gasoline-Denatured Ethanol
Pranathi P. Perati, Brian M. De Borba, and Jeffrey S. Rohrer, Thermo Fisher Scientific, Inc.
Ethanol is made from renewable energy sources and an alternative to traditional fossil fuels. Fermentation and distillation of biomass (e.g., cornstalks, vegetable waste, and any starch crop) produce fuel-grade ethanol. Although automobile manufacturers have designed flexible-fuel vehicles that can run on blends of up to 85% ethanol, most vehicles in the U.S. today operate with blends of up to 10% ethanol without the need for modification to the engine or fuel system. Read More |
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Determination of Polyacrylic Acid in Nuclear Power Plant Pressurized Water Reactor Secondary Feed Water
Lillian Chen, Brian De Borba, and Jeffrey Rohrer, Thermo Fisher Scientific, Inc.
The cost of corrosion-related failures in nuclear power plants (NPPs) is significant, prompting extensive study of corrosion-inhibiting mechanisms for nuclear power reactor systems. In pressurized water reactors (PWRs), deposit fouling in the secondary system (steam generator) can cause undesired consequences such as heat-transfer losses, corrosion of heat-exchange tubes, and reduction in plant output. Read More |
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Determination of Anions in Fracking Flowback Water From the Marcellus Shale Using Automated Dilution and Ion Chromatography
Carl Fisher, Richard Jack, and Linda Lopez, Thermo Fisher Scientific, Inc.
The rapid increase in U.S. natural gas production in recent years has been propelled by the extensive use of hydraulic fracturing (also known as fracking). This process extracts natural gas by drilling into bedrock (primarily shale) and then injecting fluid under high pressure causing cracks in bedrock, thereby releasing trapped gas that can be captured. Read More |
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Determination of Trace Sodium in Cranberry Powder
Brian De Borba and Jeffrey Rohrer, Thermo Fisher Scientific, Inc.
Cranberry powder contains organic acids, proanthocyanidins, and polyphenols. The powders are generally recognized as safe (GRAS) and can be used in beverages, foods, cosmetics, and supplements. This Application Note describes the determination of organic acids in cranberry extracts. Organic acids in cranberries impart flavors and their specific ratios can be used to detect adulteration. Read More |
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Determination of Mono-, Di-, and Triphosphates and Citrate in Shrimp by Ion Chromatography
Chanita Chantarasukon, Suparerk Tukkeeree, and Jeff Rohrer, Thermo Fisher Scientific, Inc.
Polyphosphates are legally added to some food products such as meat and seafood to improve the appearance and texture of the product and increase the weight of the seafood. Ion chromatography (IC) is commonly used to determine large and small polyphosphates, as well as citrate. Read More |
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