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June 2013 Pharma Environmental Food Rapid Determination of Benzalkonium Chloride in a Cosmetic Huang Xiongfeng, Xu Qun, and Jeffrey Rohrer, Thermo Fisher Scientific This application outlines an efficient high–performance liquid chromatography (HPLC) method for the rapid and sensitive determination of benzalkonium chloride in a cosmetic sample using a Thermo Scientific™ Acclaim™ Surfactant Plus column. This new method enables faster analysis and simpler separation conditions when compared to an existing method using the Acclaim Surfactant column. Read More Fast Analysis of Decitabine Using a Solid Core HILIC Column Prakash Chander and Tushar N. Mehta, Thermo Fisher Scientifiic This application note demonstrates the use of the Thermo Scientific™ Accucore™ HILIC column as a simple and rapid method for the determination of decitabine, an anti-cancer chemotherapy drug, and its α-anomer impurity by HPLC-UV. Read More HPLC for the Retention and Resolution of Very Polar Compounds Jamil Ali, Thermo Fisher Scientific Separation methods for extremely polar compounds have been developed using a Thermo Scientific™ Hypercarb™ HPLC column. Good retention and resolution was obtained. These methods demonstrate good reproducibility and robustness. Read More   Sensitive and Rapid Determination of Paraquat and Diquat in Tap and Environmental Waters Chen Jing, Xu Qun, and Jeffrey Rohrer, Thermo Fisher Scientific To develop an efficient high–performance liquid chromatography (HPLC) method for the sensitive and rapid determination of paraquat and diquat in tap and environmental water samples. Read More Resolving 18 PAHs, Including Benzofluoranthenes, Using the Unique Selectivity of a 50% Phenyl Methylpolysiloxane-Phased GC Column Anila I. Khan, Thermo Fisher Scientific One of the major difficulties in analyzing polycyclic aromatic hydrocarbons (PAHs) by GC–MS is achieving baseline resolution for isobaric compounds. In demonstrating the separation of 18 PAHs using a Thermo Scientific™ TraceGOLD™ TG-17SilMS GC column, the unique selectivity of this stationary phase is shown to fully resolve benzo[j]fluoranthene from benzo[b] fluoranthene and benzo[k]fluoranthene. Read More Fast Analysis of Phenols Using Conventional GC Instrumentation Anila I. Khan, Thermo Fisher Scientific This application note compares the performance of a 0.15 mm internal diameter (i.d.) GC column with a 0.25 mm i.d. GC column, and demonstrates an increase in speed of analysis for a phenol standard mix according to EPA Method 625. There was no compromise in the separation capability of the method and conversion of the conventional method was easily achieved. Read More   Fast Analysis of FAMEs Using Conventional GC Instrumentation Anila I. Khan, Thermo Fisher Scientific This application note compares the performance of a 0.15 mm internal diameter (i.d.) GC column. with that of a 0.25 mm i.d. GC column. An increase in the speed of analysis for a 14 component fatty acid methyl ester (FAME) reference standard C8–C24 mix is demonstrated using the 0.15 mm GC column. No compromise in the separation capability of the method was observed, and conversion of the conventional method was easily achieved. Read More A GC-FID Method for the Comparison of Acid- and Base-Catalyzed Derivatization of Fatty Acids to FAMEs in Three Edible Oils Anila I. Khan, Thermo Fisher Scientific This application note demonstrates the analysis of 37 fatty acid methyl esters (FAMEs) separated by a highly polar phased Thermo Scientific™ TRACE™ TR-FAME GC column. Results from two derivatization methods (acid and base esterification) were compared for their efficiency in converting fatty acids to their methyl esters on three different fat matrices prior to GC analysis. Read More   Go to Application Note Library Subscribe to the Application Note Alert LCGC Print Edition LCGC Digital Edition