Sub ug/L Level analysis of chlorinated pesticide and herbicide Analysis in water by GC/u ECD using Agilent J&W DB35ms Ultra Inert GC column
Ken Lynam and Doris Smith, Agilent Technologies

This app note demonstrates the consistent and sensitive analysis for the chlorinated compounds at and below established maximum contaminant concentrations when using a dual column GC/uECD approach using the Agilent J&W DB035msUI GC column.

Determining Phenolic Compounds in Whisky
Eike Kleine-Benne, Ph.D. and Yunyun Nie, GERSTEL

LVI-GC/MS and SBSE-TD-GC/MS  are evaluated for quantitative determination of seven phenolic compounds in whisky with no or little sample preparation. Whereas both techniques provide good linearity and reproducibility, SBSE delivers lower LODs and LOQs.

Hydrogen as an alternative to Helium for gas chromatography
Peter Adam, Linde AG, Linde Gas Division, Germany, Linde Gas

Many gas chromatographers are considering hydrogen carrier gas instead of helium or nitrogen, but they might hesitate to do so because they have questions about performance, safety and cost. This guide presents the basic steps to safely convert from helium to hydrogen as a carrier gas for gas chromatography. It presents useful data to estimate costs and demonstrates the excellent separation performance of hydrogen.

Volatile Compounds in Beer
Lee Marotta and Andrew Tipler, PerkinElmer, Inc.

This application note describes a system comprising a headspace trap sampler to extract and concentrate volatile organic compounds from a beer sample and deliver them to a gas chromatograph/mass spectrometer (GC/MS) for separation, identification and quantification.

Fast Simulation of Drug Metabolism Using Electrochemistry-MS
A. Kraj, H-J. Brouwer, M. Eysberg, and J-P. Chervet, Antec

For faster, better, and superior simulation of drug metabolism, Antec has developed a dedicated electrochemistry system, called ROXY™ EC. The system is used up-front MS and allows for the generation and screening of potential metabolites, mimicking P450 enzymatic reactions in a few seconds without any biological interferences.

Automated Solid Phase Extraction of Semi-Volatile Organic Compounds (AB 8270 SIM) in Water
Phil Bassignani, FMS, Inc.

EPA Method 8270 is used to determine the concentration of semi-volatile organic compounds in extracts prepared from solid waste matrices such as soils, air sampling media and water samples. The following application outlines the complete automation of a modified 8270 extraction, delivering a complete, out-of-the box MDL study demonstrating both precision and accuracy for mixed classes of low-level analytes.

Extraction of Vitamin D from Serum using SLE+
Rhys Jones, Lee Williams, Biotage AB, Sweden

This method describes the use of ISOLUTE SLE+ plates for the efficient and simple extraction of the vitamin D metabolites 25-OH vitamin D2 and 25-OH vitamin D3. Incorporated into the procedure is an integral protein binding disruption step which maximizes analyte recovery and eliminates the need for any offline protein disruption.  All recoveries were consistently greater than 90% with all RSDs < 10% at LOQs of 1-3.75 ng/mL.

Identification of Nanoparticles in Instant Cappuccino
Petra Krystek and Thomas Jocks, Wyatt Technology

Nanoparticles have made their way into numerous consumer products that are used by hundreds of millions of people. This torrid pace of development is paralleled by the need to collect reliable data on the distribution and behavior of these particles. The characterization of nanoparticles represents a pivotal step in the quality control of the production process.