Current Trends in Mass Spectrometry e-newsletter:
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Presented by LCGC and Spectroscopy

July 23, 2013





Featured Articles
Mass Spectrometry — Sustaining Growth in a Challenging World
This article provides a focused outlook on how laboratory mass spectrometry (MS) techniques will fare this year compared to 2012. We look specifically at triple-quadrupole MS, Fourier transform MS, quadrupole time-of-flight MS, ion-trap MS, inductively coupled plasma–MS, matrix-assisted laser desorption–ionization time-of-flight MS, and magnetic sector instruments as well as the clinical market and government demand. Finally, we examine the competitive landscape in these areas.
Sample Preparation Guide for Mass Spectrometry–Based Proteomics
Sample preparation is an integral, but sometimes neglected, part of a successful mass spectrometry (MS)-based proteomics experiment. Good sample preparation techniques require a profound understanding of the biological samples to be analyzed and of the liquid chromatography (LC)–MS process. This review article summarizes successful sample preparation strategies that led to some of the highest peptide and protein identification rates reported in the literature. MORE »
Increase Accuracy of FTIR Analysis
Read study demonstrating the inconsistency in background levels of water and CO2 for an unpurged, sealed, and desiccated FTIR spectrometer as compared to a sealed and desiccated FTIR spectrometer with the sample compartment purged. The purge enhances instrument reliability by reducing the need for maintenance and increases the accuracy of analysis by eliminating inconsistencies in background levels of CO2 and to download paper.
Rapid and Specific Determination of Contaminants, By-Products, and Additives in Insulating Mineral Oils with Tandem Mass Spectrometry
This article demonstrates the use of electrospray ionization–mass spectrometry for rapid and specific determination of widely used metal deactivators Irgamet 30 and Irgamet 39. The article also presents specific quantitative determination of a highly corrosive sulfur compound dibenzyl disulfide and its principle nonsulfur by-product bibenzyl with gas chromatography and tandem mass spectrometry (GC–MS-MS). MORE »
Using GC–MS to Observe Changes in the Essential Oil Concentrations in Cedar Tree (Juniperus virginiana) Leaves During a Drought Year
Essential oils were extracted from the leaves of cedar trees using ~50 mL of methylene chloride with an internal standard, m-xylene. The extract was then concentrated to ~2.0 mL by boiling off the solvent and analyzed by gas chromatography–mass spectrometry (GC–MS). Samples were collected monthly and the results were compared to weather data for an entire year, during a drought. MORE »
Introducing the SPECTROSCOPY App for your iPhone or iPad
Designed for both the iPhone and iPad, Spectroscopy’s new app may be found on iTunes, under the Business category, and downloaded for free. Exploring the latest news and trends for spectroscopists has never been easier.
Download it for free today at
Ultrahigh-Performance Liquid Chromatography–Mass Spectrometry in Lipidomics
This article describes an analytical method for the global profiling of molecular lipids in biological samples, with particular emphasis on the plasmalogen lipids. The global profiling method is based on ultrahighperformance liquid chromatography combined with quadrupole time-of-flight-mass spectrometry (UHPLC–QTOF-MS). The profiling approach is complemented by UHPLC–orbital trap MS in MS n mode for de novo lipid identification. MORE »
Applying Comprehensive Analysis to EPA Method 1613B Samples — Discover Those Compounds Usually Discounted in Environmental Samples
Polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) are ubiquitous environmental pollutants that are persistent and toxic. The historical quantitative analysis of these compounds has been achieved with high-resolution targeted analysis using magnetic sector instruments, with subsequent lower resolution analysis to identify other contaminants. Advances in technology have led to comprehensive time-of-flight (TOF) mass spectrometers that can quantify PCDDs or PCDFs while simultaneously acquiring data on other contaminants in the samples. MORE »
Featured Product
PerkinElmer Introduces a New Generation of Tandem Mass Spectrometer
The AxION® iQT™ GC/MS/MS system is the first mass spectrometry platform of its kind.  This revolutionary solution combines the quantitative performance of a triple quadrupole with the identification capabilities of a Q-TOF in a faster, modular and easier to operate instrument.  Compatible with leading gas chromatographs, the AxION iQT measures compounds over 50 times faster than any quadrupole without compromising sensitivity, and its self-registering Smart Modules optimize system performance for simplified maintenance and enhanced uptime.Click here to find out more
Innovative Vial Design
Thermo Scientific™ SureStop™ vials, designed as part of the Advanced Vial Closure System (AVCS), remove subjectivity around achieving the optimal seal compression when closing a vial. SureStop vials offer the sealing and performance characteristics of a crimp top vial with the versatility and convenience of a threaded vial. The positive feedback design of the vial finish prevents over tightening of the closure.Learn more
Collect Data – Not Samples
The TRIDION™-9 GC-MS is your solution for collecting and analyzing samples at their location, whether in the field, in a manufacturing facility, or in public spaces all within minutes of collection.Learn more
New Webcast
How to Avoid Bad Data When Analyzing Routine QA/QC Industrial Samples Using ICP-OES and ICP-MS
Tuesday, September 10, 2013
8:00 am PDT/ 11:00 am EDT; 16:00 BST; 17:00 CEDT
Do you want to find out how to verify your QA/QC data quality or discover the best practices for avoiding common errors that result in bad data?  Then join this educational webinar to learn how to achieve “right first time” data. Sign Up Now>>
USP <232> and <233>: Practical Considerations for Compliance with the New Requirements on Elemental Impurities
Thursday, September 19, 2013
10:00 am PDT/ 1:00 am EDT
You probably already know the basics of what USP<232> and <233> means to your lab. Now, learn about the tools available to rapidly get your operation compliant. Learn how to choose the right technique, how to use the PerkinElmer “J” value calculator, the critical role of 21 CFR Part 11 compliance software, and how you can simplify the setup, calibration and maintenance of your system. Sign Up Now>>

Upcoming Events
28 July–1 August 2013
2013 AACC Annual Meeting
Houston, TX
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4–8 August 2013
Microscopy & Microanalysis 2013 Meeting
Indianapolis, IN
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12–14 August 2013
CoSMoS 2013
San Diego, CA
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25–29 August 2013
Warsaw, Poland
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20 September – 4 October 2013
SciX2013 – The Great SCIentific eXchange
Milwaukee, WI
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30 September – 4 October 2013
10th Confocal Raman Imaging Symposium
Ulm, Germany
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