| Featured Articles |
Development of an Ultrasensitive LC–MS-MS Method for Determination of 5-Fluorouracil in Mouse Plasma
5-Fluorouracil (5-FU) is a low-molecular-weight anticancer drug in clinical use for several solid tumors in humans. Currently, the most widely used methodology for 5-FU quantitation is liquid chromatography–tandem mass spectrometry (LC–MS-MS) with either liquid–liquid extraction (LLE), protein precipitation, or a combination of both as sample cleanup procedures. MORE » |
Development of a Quantitative SPE-LC/MS/MS Assay for Teriparatide in Human Plasma
This study provides a single, simple method for the quantification of teriparatide in human plasma. The method uses UPLC and fast, selective sample prep in 96-well format to achieve a limit of detection (LOD) of 15 pg/mL, a dynamic range of 15 to 500 pg/mL, and an average QC accuracy of 97.5% (across six sources of matrix) from 200 μL of human plasma. Learn more
|
|
Application of Paper Strip Extraction in Combination with LC–MS-MS in Pharmacokinetics
Recent advances in sampling techniques in the pharmaceutical industry sparked significant interest in applying improvements to extraction methods for greater analyte detection and quantitation. MORE » |
Download LCGC's New E-Book: Innovations in Environmental Analysis
No matter what type of environmental testing you do, you need the latest methods. This new special issue is here to help, by bringing together vital information on methods for environmental analysis. Sponsored by Thermo Scientific.
 Download Today |
|
Life Science Applications of Electrochemistry Coupled to Liquid Chromatography–Mass Spectrometry
Redox reactions are integral parts of many cellular processes. Thus, they are extensively studied in vitro and in vivo. Electrochemistry (EC) represents a pure instrumental approach to characterize direct and indirect effects of redox reactions on bioorganic molecules. MORE » |
| Featured Product |
 |
NEW Thermo Scientific™ TSQ Quantiva™ and TSQ Endura™ triple-stage quadrupole mass spectrometers
Delivering extreme performance and value with unprecedented robustness and ease of use. Applications Compendium for Food Safety Analysis. available now! |
|
Comprehensive Analysis of Human Plasma Using Gas Chromatography–High Resolution Time-of-Flight Mass Spectrometry: A Workflow to Leverage Electron and Chemical Ionization
Gas chromatography with electron ionization and mass spectrometry (GC–EI-MS) detection is a workhorse among analytical techniques in metabolomics. A major challenge in the utilization of GC–EI-MS in metabolomics is the identification of unknowns. MORE » |
| New Webcast |
High Speed AFM-Raman Optimized for Nanoscale Chemical Imaging: Making TERS An Accessible Technique
Thursday, November 12, 2013 11:00 am EST
Attend this web seminar to learn how ultrafast and simultaneous AFM-Raman optimized for Tip-Enhanced Raman imaging can be used to
- Reveal nanoscale physical properties with chemical information
- Extend chemical property resolution well below the diffraction limit
- Map details of properties within individual nano-particles and identify what gives rise to their special properties
Sign Up Now>>
|
