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May 23, 2013
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Chromatography News

Analytical Quality by Design in the Pharmaceutical Industry
LCGC spoke to Rosario LoBrutto, TEVA Pharmaceuticals (Pomana, New York), on the business benefits of Analytical Quality by Design and practical aspects of implementing this approach.
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Featured Product

Mass Spectrometry Transformed
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about our new mass spectrometers.
3 Easy Steps:

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  • Click on the email links we send 12 pm Central Time on Sunday, June 9.
  • Learn how our new products can transform your science
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Featured Article

Advances in Hydrophillic Interaction Liquid Chromatography for Pharmaceutical Analysis
Hydrophilic interaction liquid chromatography (HILIC) has recently become more important, particularly for the analysis of polar drugs, metabolites, and biologically relevant compounds in glycomics, proteomics, metabolomics, and clinical analysis. HILIC makes it possible to increase the retention of polar compounds, achieve orthogonal selectivity, and increase mass spectrometry (MS) sensitivity, compared with reversed-phase liquid chromatography. This article discusses the advantages and limitations of HILIC in a variety of practical applications in the pharmaceutical industry.
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UltiMate 3000 Rapid Separation Systems
Developing and manufacturing drugs requires unique skills and extremely flexible LC instrumentation. Thermo Scientific’s UHPLC and HPLC-compatible Rapid Separation (RS, XRS, BioRS) systems not only offer exceptional workflow automation tools and unique detection technologies, but are truly designed around your laboratory workflows. With adjustable gradient delay volumes and powerful software tools, the UltiMate™ 3000 UHPLC platform gives you more data while requiring fewer resources and fewer experiments.
www.thermoscientific.com/UHPLCpharma
 
Assay for Parts-Per-Million Levels of Azide in Drug Substances
The removal of azide as a potential impurity from a drug substance may be critical to its safety profile, such that quantitation of this impurity becomes an important control parameter. This article describes a simple and practical assay for azide using chemical derivatization and high performance liquid chromatography. The method is shown to be suitable for the intended purpose on three example test materials. Potential issues for wider applications are discussed.
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Featured News

The Science of Aboriginal Smoking Ceremonies
Two researchers from the University of New England in Armidale, Australia, have investigated the traditional medicines used in Australian Aboriginal cultures using gas chromatography–mass spectrometry (GC–MS) and gas chromatography with flame ionization detection.
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LC Troubleshooting

Need Help With LC Troubleshooting?
A free interactive LC Troubleshooter is now available at CHROMacademy, sponsored by Thermo Scientific. In 3 simple steps you will overcome your instrument, separation and quantitation issues. It's completely free.
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Screening Drugs in Saliva
A team of scientists from Stockholm University in Sweden has developed a method for screening and determining drugs in human saliva using microextraction by packed sorbent (MEPS) and liquid chromatography tandem mass spectrometry (LC–MS–MS).
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New Webcasts
Solving One of Chromatography’s Biggest Dilemma — Proper Sealing of Chromatography Autosamper Vials — Using the Advanced Vial Closure System (AVCS)
Thursday, June 6, 2013
8:00 am PDT/ 11:00 am EDT/ 16:00 BST/ 17:00 CEDT.
This web seminar will review the impact an innovative vial & closure design, like AVCS, can have on improving data quality by providing data that supports how an AVCS-designed vial & closure eliminates under and over compression of vial seals while improving robotic autosampler pick-up of vials, ensuring more centered vial closure positioning and greater optical recognition of vials placed in autosamplers.
 
Multi-Residue Pesticide Analysis in Herbal Products Using Accelerated Solvent Extraction with Triple Quadrupole
Wednesday, June 25, 2013
8:00 am PDT/ 11:00 am EDT/ 16:00 BST/ 17:00 CEDT.
As the human population grows and farm acreage shrinks, the use of pesticides has increased, in order to produce food efficiently. Regulatory organizations are therefore requiring manufacturers to present test data on pesticide levels in food to address public safety concerns. Sensitive and robust routine screening methods to analyze hundreds of potential contaminants are therefore necessary.
 
 
Upcoming Events

 
6–7 June 2013
European Lab Automation 2013
Hamburg, Germany
» Visit the website
 
9–13 June 2013
61st ASMS Conference on Mass Spectrometry and Allied Topics
Minneapolis, MN
» Visit the website
 
16–20 June 2013
HPLC 2013: 39th International Symposium on High-Performance Liquid-Phase Separations and Related Techniques
Amsterdam, The Netherlands
» Visit the website
 
18–20 June 2013
Green Chemistry & Engineering Conference (GC&E)
Bethesda, MD
» Visit the website
 
25–28 June 2013
Air & Waste Management Association 106th Annual Conference
Chicago, IL
» Visit the website
 
30 June–3 July 2013
24th International Symposium on Pharmaceutical and Biomedical Analysis
Bologna, Italy
» Visit the website
 
2–5 July 2013
In Vino Analytica Scientia
Reims, France
» Visit the website
 
4–17 July 2013
PREP 2013 — 26th International Symposium
Boston, MA
» Visit the website
 
7–12 July 2013
Chirality 2013
Shanghai, China
» Visit the website
 
13–16 July 2013
IFT’s 2013 Annual Meeting & Food Expo
Chicago, IL
» Visit the website
 
21–24 July 2013
50th Annual North American Chemical Residue Workshop
St. Pete Beach, FL
» Visit the website