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December 4, 2014
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The LCGC Blog

The LCGC Blog: Are we scared to properly explore selectivity options in HPLC?
Much has been written about options for increasing efficiency in HPLC – primarily through the use of core shell and sub 2 μm particles, which have been used to increase efficiency, speed up separations or increase peak capacity. However, many separations can only be effectively improved, by optimising selectivity – resolution is a function of selectivity, efficiency and retention, with selectivity being the most effective at achieving good resolution. More...
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New-Carbon-Based Phases for 2D LC
In this new video clip from LCGC TV, Dwight Stoll of Gustavus Adolphus College discusses the development of new carbon-based phases for 2D LC that are well characterized and understood. More...
More Efficiency, More Free Time
All you expect, and more. The new Agilent 1290 Infinity II LC sets new benchmarks in analytical, instrument and laboratory efficiency. You may find yourself with extra time on your hands.
Meet the next generation of Agilent UHPLC:
How Much Can I Inject? Part II: Injecting in Solvents Other than Mobile Phase
What happens if we use an injection solvent that is stronger or weaker than the mobile phase? After all, many times the sample comes to us in something other than the mobile phase, and we'd rather not add sample preparation steps to transfer the sample to a new solvent. Or sometimes the sample is too dilute to see an adequate signal if we stick to the 15% Rule — is there a way to increase the injection volume while mitigating unwanted peak broadening? All the examples so far have been for isocratic separation — how does it work for gradients?. More...
Get end-of-year discounts when you trade up to higher performance
Take advantage of special end-of-year savings on Thermo Scientific™ UHPLC and
LC-MS triple quadrupole systems. Act now to upgrade your laboratory's capabilities to the latest technology and be more productive in 2015.Learn more
Need Help With LC Troubleshooting?
A free interactive LC Troubleshooter is now available at CHROMacademy, sponsored by Thermo Scientific. In 3 simple steps you will overcome your instrument, separation and quantitation issues. It's completely free. More...
LCGC E-Book: Controlling Selectivity in Reversed-Phase LC
Reversed-phase liquid chromatography (LC) is the most common mode of liquid chromatography, and a powerful analytical tool. Getting the most from it, however, requires achieving the selectivity needed for your specific separation. In this e-book, John Dolan, renowned LC expert and the longtime author of the "LC Troubleshooting" column in LCGC presents four steps to controlling selectivity in reversed-phase LC. Download Today

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New Webcasts
Editors’ Series: Multiclass, Multiresidue Monitoring of Veterinary Drug Residues in Food Animal Tissues
Wednesday, December 3, 2014 8:00 am PST/ 11:00 am EST
Streamline Data Analysis of Tandem Mass Spectrometry for Inborn Errors of Metabolism Research
Wednesday, December 10, 2014 8:00 am PST/ 11:00 am EST/ 4:00 pm GMT/ 5:00 pm CET
Fast and Accurate Analysis of Beer and Wort Samples Using Automated Discrete Analysis
Thursday, December 11, 2014 8:00 am PST/ 11:00 am EST/ 4:00 pm GMT/ 5:00 pm CET
On Demand Webcasts
Editors’ Series: The Use of Silica Hydride-Based Stationary Phase for the HPLC Analysis of Food and Beverage Products
Future-proofing Your GC-MS Analysis: Triple Quad Workflows on Demand
Editors’ Series: Quality Control of Dietary Supplements: An Examination of Chromatographic Approaches Needed for cGMP Compliance, with Case Studies