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LCGC North America | e-Separation Solutions
April 21, 2016
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The HPLC 2016 Previews—Trends in Separation Science

State-of-the-Art MS Methods for Structural Assessment of mAbs and ADCs: From the Research Lab to Routine Characterization
Multilevel state-of-the-art mass spectrometry methods, combined with chromatographic and electrophoretic techniques, enable very precise characterization of biotherapeutics. These techniques are now amenable for routine use, as several examples illustrate.

This is the fourth in a series of four articles exploring topics that will be addressed at the HPLC 2016 conference in San Francisco, from June 19 to 24.
Efficiency is seamless method transfer
Retire your legacy instruments without retiring your validated methods! Make a smooth transition to maximum lab efficiency using the Agilent 1290 Infinity II LC with Intelligent System Emulation Technology (ISET) Get the facts at http://efficientUHPLC.agilent.com
The LCGC Blog

Practical HPLC Method Development Screening
This installment of The LCGC Blog discusses the other important aspects of screening in HPLC, which include the mobile phase composition, gradient parameters, and flow rate.
Glycan Permethylation µ-Reactor™ Columns
New! Glycan Permethylation µ-Reactor™ Empty Columns with caps (SUM 0000-BW) permit solid-phase permethylation and NaOH removal, all from an enclosed container. Reduce artifacts! Try our  Reactor columns today! The Nest Group, Inc. - "Not Just Columns … Answers!" Learn more
LCGC TV

Nanoparticle Characterization: What We’ve Learned About Toxicity
A particle with unique characteristics is very important in analytical science. Luis Colon from the State University of New York at Buffalo reveals what his studies involving carbon dots and HPLC have uncovered about these nanoparticles.
Histidine Removal Columns Improve Mab Stability Assays
New! HisSep™ Spin Columns remove histidine from antibody formulations increasing the accuracy of amino acid and electropherogram (icIEF) assays.  Reduce artifacts from protein-histidine absorption! Try our HisSep spin columns today! The Nest Group, Inc. - "Not Just Columns … Answers!" Learn more
Take Our Quick Poll

Data Integrity in the Lab
Data integrity in the laboratory is currently a hot topic. What is your company or laboratory doing about it? Take our quick poll today! The results will appear in an upcoming issue of LCGC magazine.
Featured Articles

Retention Time Drift—A Case Study
What should you do if your retention times drop from one injection to the next? A systematic approach to troubleshooting can help to quickly identify the problem source.

Biochromatography Size-Exclusion and Ion-Exchange Techniques
What can these techniques tell us from a qualitative and quantitative perspective?
 
Featured Products
Abalonase™ and Abalonase™+ Purified Beta-Glucuronidase IDEX Corp Easy Method Transfer
Ultra-pure Abalonase™ can deconjugate the major metabolites of interest including benzodiazepines, opioids, cannabinoids, and steroids. For the deconjugation of both glucuronidated and sulfated metabolites, Abalonase™+ is enriched with 4 arylsulfatses. Learn more Ensure a secure fluidic path with Ultra High Pressure Multiport Connectors specialized for UHPLC applications. These robust connectors deliver zero dead volume (ZDV) and withstand pressures of up to 30,000psi.
Learn more		 TSKgel UP-SW3000, 2 µm SEC columns are designed for the analysis of monoclonal antibodies and other biopharma products. They are compatible with both HPLC and UHPLC systems for ease of method transfer. Learn more
 
New Webcasts
Improving Quantitative Sensitivity for Monoclonal Antibodies
Tuesday, April 26, 2016
7:30 am PDT/ 10:30 am EDT/ 3:30 pm BST/ 4:30 pm CEST

Industrializing Quantitative Proteomics Using Microflow LC and SWATH® Acquisition
Wednesday, April 27, 2016
7:30 PDT / 10:30 am EDT / 3:30 BST / 4:30 CEST
 
On Demand Webcasts