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| The HPLC 2016 Previews—Trends In Separation Science |
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Reconsidering HIC for Top-Down Proteomics
Until recently, mass spectrometry (MS) was limited in the information it could supply regarding proteins larger than 40 kDa. The most recent instruments have broken through that limit, but proteins smaller than 40 kDa are still more easily detected in MS and can suppress the collection of data from larger proteins. This situation has created a demand for better separation of proteins upstream from the MS orifice. At present, though, this separation of proteins is something of a bottleneck. Methods such as reversed-phase chromatography that involve mobile phases compatible with MS are not compatible with many proteins. Alternative modes of chromatography include size-exclusion chromatography, ion-exchange chromatography, hydrophilic interaction chromatography (HILIC), and hydrophobic interaction chromatography (HIC). We decided to take another look at HIC.
This is the third in a series of articles exploring topics that will be addressed at the HPLC 2016 conference in San Francisco, from June 19 to 24. |
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| LCGC TV |
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The World’s Most Powerful Mass Spectrometer—Accessible to All
The 21 Tesla FT-ICR-mass spectrometer is part of a National Science Foundation user facility, and is available free of charge to anyone who wants to come use it. In the latest clip from LCGC TV, Alan G. Marshall discusses the range of different groups that use the system. |
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| The LCGC Blog |
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Practical HPLC Method Development Screening
A frequently asked question about the other important aspects of “screening” in HPLC, which include the mobile phase composition, gradient parameters, and flow rate, inspired the theme of this installment of The LCGC Blog. |
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| Featured Articles |
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| Advances in Separations Technologies |
Interested in mass spectrometry, chromatography, or electrophoresis? Looking for a conference with strong scientific content, robust program, world renowned speakers, poster sessions, courses, workshops, tutorials, panel discussions, major exposition showcasing new product launches? Check out HPLC 2016 San Francisco...largest, most recognized international conference and exposition devoted to advances in separations technologies, leading the way to ensure the separation sciences remain a powerful analytical tool.  Learn more |
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| Featured News |
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Featured Products
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| Automated canister analysis |
Wyatt |
The CIA Advantage is a multi-channel cryogen-free autosampler and VOC pre-concentrator for canister samples of air or gas analysed using GC, and is compliant with US EPA Method TO-15.
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The µDAWN™ is the world's first multi-angle light scattering (MALS) detector that can be coupled to any UHPLC system in order to determine absolute molecular weights and sizes of polymers, peptides, and proteins.  Learn more |
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| Electronic Maintenance Indicators for Gas Filters |
Wheaton Automatic Crimping Tools |
Restek's electronic maintenance indicator is a monitoring device that warns you when planned maintenance for a gas filter is due. Prevent unexpected downtime by controlling your routine maintenance schedule with an electronic maintenance indicator from Restek.
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The Wheaton Automatic Crimping Tools are built for durability and ergonomics, helping laboratory professionals easily crimp high volumes of sample vials without significant discomfort or distress.
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