With 2018 now in full swing, the LCGC editorial team looks back at 17 of the top chromatography articles of 2017.

1. New Advice on an Old Topic: Buffers in Reversed‑Phase HPLC

A model set of analytes and selected applications demonstrates the effects buffers can have on the selectivity of a separation and the sensitivity of a reversed-phase analysis when using MS detection. Read more

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2. Where Separation Science is Heading

Leading separation scientists share their perspectives on current challenges that still need to be solved and their vision for what is to come—or should be coming—in separation science. Read more

Struggling with EtG/EtS matrix interferences?

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3. UHPLC, Part I: Perspectives and Instrumental Features

In this three-part series, we assess how UHPLC evolved into a modern platform. We start by examining the most important features common to most commercial instruments. Read more

4. Back to Basics: The Role of pH in Retention and Selectivity

Mobile-phase pH is a powerful tool, but must be controlled properly. Read more

5. The LCGC Blog: Ghost Peaks in Gradient HPLC

The secret to understanding the phenomenon of ghost peaks lies in understanding the mechanisms of gradient HPLC. Read more

6. Liquid Chromatography–Time-of-Flight Mass Spectrometry for Cannabinoid Profiling and Quantitation in Hemp Oil Extracts

The method presented here allows for the accurate, precise, and robust speciation, profiling, and quantification of cannabinoids in hemp oil extracts and commercial cannabinoid products for research and development laboratories. Read more

7. Utility of the Summation Chromatographic Peak Integration Function to Avoid Manual ReIntegrations in the Analysis of Targeted Analytes

We present an empirical assessment of summation integration involving 490 low-pressure GC–MS/MS analyses of 70 pesticides in 10 common fruits and vegetables over the course of 10 days. Read more

8. The Use of Extraction Technologies in Food Safety Studies

New extraction techniques can improve the accuracy and precision of analytical results and simplify analytical procedures. Read more

9. Improving GC Performance Systematically

Changing just one variable at a time is often the best approach. Read more

10. Column Care for the Long Haul—Considerations for Column Storage

We consider some of the details associated with preparing a column for storage, with an eye toward choices that will pay dividends in future use. Read more