| Chromatography Corner |
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Monitoring Drug Behavior Using High Performance Affinity Chromatography (HPAC)
There is a growing demand in the pharmaceutical industry for fast and selective separation methods to monitor drug behavior in small-volume biological samples. David S. Hage from the University of Nebraska–Lincoln, USA, has recently developed a series of methods using affinity chromatography and related techniques for this purpose. LCGC interviewed him on this work. |
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| Featured Articles |
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New FDA Guidance on Analytical Methods Provides General Approach, but Few Details
The new US FDA guidance document, Analytical Procedures and Method Validation for Drugs and Biologics, is very general in nature. Anyone hoping for specific recommendations on topics such as which methods to use will be disappointed. Industry experts, however, say that it really isn’t feasible for the FDA to provide detailed recommendations about analytical methods for biopharmaceuticals. |
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Separation Science in Drug Development, Part I: High-Throughput Purification
This installment provides an overview of modern practices of high-throughput purification to support small-molecule drug discovery. It describes the use of reversed-phase liquid chromatography (LC) and supercritical fluid chromatography (SFC) for purifying diverse samples in a centralized laboratory setting. A case study is used to illustrate the principles and rationales for selecting operating parameters for these applications. |
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Resources for Pharma Analysis & Mass Spectrometry
We all know that pharmaceutical analysis is full of complexity. The Chromatography Solution Centers, developed by LCGC in coordination with a leading supplier, can help — by providing a variety of articles, application notes, videos, and other resources — updated monthly. This month's offering includes the Mass Spectrometry Solution Center |
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| Chromatography News |
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Critical Choices in HPLC
In chromatography, the better your understanding of the fundamental mechanisms, the easier it will be for you to develop successful methods. This new e-book provides a guide to essential information in HPLC. Download PDF |
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| Featured Products |
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| New Thermo ScientificTM Orbitrap FusionTM LumosTM TribridTM Mass Spectrometer |
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