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Formulary E-News
May 7, 2010
TOP SEARCHES: Type 2 diabetes // Osteoarthritis pain // Hepatitis C drugs
In this issue
Health reform results
Liraglutide superior
Cotrimoxazole and warfarin
Antiepileptic drugs
Niacin use
FMCP winners
Anticonvulsant risk
Gout treatment revisited
Key Topic Updates

Survey

This month we would like to know...

In your opinion which of the following components of healthcare reform will have the most significant impact, positive or negative, on your organization's management of its pharmacy program?

a) Expanded access to coverage for more Americans
   
b) New regulatory path for biosimilar approval
   
c) Increased Medicaid drug rebating
   
d) Enhanced support for comparative effectiveness research
   
e) Closure of Medicare Part D 'doughnut hole'
   
f) Enhanced funding for health information technology

Vote in our survey, and see what other P&T committee members have to say.
Click here to vote

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Your response to healthcare reform
Since Congress passed healthcare reform legislation in March, Formulary has continued to ask for your feedback. Here is your response. More...
Liraglutide found superior to sitagliptin for reduction of HbA1c in type 2 diabetics
Liraglutide offered superior glycemic control to sitagliptin in patients with type 2 diabetes who had inadequate glycemic control on metformin, according to a recent report in The Lancet. More...
Cotrimoxazole tied to bleeding in older patients on warfarin
In older patients treated with warfarin, the use of cotrimoxazole is associated with a higher risk of upper gastrointestinal (UGI) tract hemorrhage than other common antibiotics, according to research published in the April 12 issue of the Archives of Internal Medicine, as reported by HealthDay News. More...
Lamotrigine may be most effective antiepileptic drug
Of 10 antiepileptic drugs (AEDs) studied in older adults with epilepsy, lamotrigine closely followed by levetiracetam is the most effective, as measured by 12-month retention and freedom from seizures, while oxcarbazepine is consistently less effective than other AEDs, according to research published in the April issue of the Archives of Neurology, as reported by HealthDay News. More...
Niacin superior to ezetimibe in decreasing CIMT
Patients with coronary heart disease (CHD) or CHD equivalent on stable statin monotherapy treated with the addition of extended-release niacin have significant decreases in carotid intima-media thickness (CIMT) compared with those who had ezetimibe added to their stable statin treatment, according to a study published online April 14 in the Journal of the American College of Cardiology, as reported by HealthDay News. More...
FMCP tabs winners of P&T and poster competition
The Board of Trustees of the Foundation for Managed Care Pharmacy (FMCP), the educational and philanthropic arm of the Academy of Managed Care Pharmacy (AMCP), announced the winners in the 10th Annual AMCP/FMCP National Student Pharmacist Pharmacy & Therapeutics (P&T) Competition, and FMCP Best Student Pharmacist and Best Resident or Fellow Poster Contests. The awards were presented in April at AMCP�s 22nd Annual Meeting & Showcase in San Diego, Calif. More...
Some anticonvulsants may raise suicide risk
Anticonvulsant agents have important therapeutic benefits. However, both the healthcare provider and patient need to remain cognizant of associated risks, according to results of a study published in the April 13, 2010, edition of the Journal of the American Medical Association. More...
Low-dose colchicine found to be as effective as high-dose regimen for early gout flares
Low-dose oral colchicine is just as effective as high-dose colchicine in reducing pain associated with early acute gout flare, but with a safety profile statistically indistinguishable from placebo, according to a study published in the April issue of Arthritis & Rheumatism, the official journal of the American College of Rheumatology. More...
Key Topic Updates
FDA Approvals
Velaglucerase alpha for injection (VPRIV): An enzyme replacement therapy approved as a long-term treatment for type 1 Gaucher disease
Dalfampridine (Ampyra): A potassium channel blocker approved as a treatment to improve walking in patients with multiple sclerosis
FDA actions in brief, April 2010 (Silenor, Carbaglu, Hizentra, Norditropin FlexPro, Xifaxan, Differin, Botox)
First-time generic approvals April 2010

In the Pipeline
FDA Pipeline preview, April 2010 (Miglustat, Insulin human inhalation powder, APF530, Exenatide LAR, Pirfenidone, ACU-4429, L-asparaginase, Alpha1-proteinase inhibitor, LIPO-102, QPI-1002/I5NP, MA09-hRPE, ARC1779, Ciprofloxacin dry powder inhaler, CK-2017357, GVAX Pancreas Vaccine)

Policy News
FDA information systems, Sentinel Initiative seek more timely drug safety information

Clinical Meeting Coverage
ACEI and ARB use in pregnancy an increasing concern
Genetic testing may provide more accurate warfarin dose, lower risk of bleeding and clots
Ticagrelor use leads to lower mortality after coronary artery bypass graft survey

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