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Formulary, A peer-reviewed drug management journal for managed care and hospital decision-makers
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FormularyJournal.com

April 8, 2011

Formulary
Home Medication Safety FDA Actions Latest News Policy Watch Drug Watch
In This Issue
Combination of ACEI and ARB therapy increases renal risks in elderly
Suppressive therapy manages clopidogrel hypersensitivity
Tiotropium superior to salmeterol in preventing exacerbations in COPD
FDA won't take action against pharmacies that compound Makena
Rheumatic disease patients may require 2 doses of flu vaccine

Survey

Last month's survey results:

Do you support The Preserving Access to Life-Saving Medicines Act, which would increase FDA's authority to prevent prescription drug shortages?
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Yes: 83%

No: 17%

This month we would like to know...

Fingolimod (Gilenya) was recently FDA approved in the treatment of relapsing remitting multiple sclerosis (RRMS). How is your health system covering or planning on covering this new oral disease-modifying therapy (DMT)?

1) We will be/are covering it only for patients who have failed injectable DMTs (both in the interferon class and glatiramer acetate).

2) We will be/are covering it only for patients who have failed injectable DMTs (either an interferon or glatiramer acetate).

3) We will be/are covering it for patients that meet certain criteria. However, the main criteria does not have to be failure of an injectable DMT.

4) We will be/are covering it for patients with a new diagnosis of RRMS only.

5) We will not be covering it at all until more data is available.

6) We have not yet decided how to cover this product.

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Combination of ACEI and ARB therapy increases renal risks in elderly

Combining angiotensin-converting-enzyme inhibitors with angiotensin-receptor blockers is associated with increased risk of adverse renal outcomes, according to a recent study published in the Canadian Medical Association Journal. Read full article.

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Suppressive therapy manages clopidogrel hypersensitivity

Clopidogrel hypersensitivity, which affects 6% of patients, can be successfully treated using short-course corticosteroids and antihistamines without interrupting drug therapy, reported researchers at Jefferson Medical College in Philadelphia. Read full article.

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Tiotropium superior to salmeterol in preventing exacerbations in COPD

The anticholinergic drug tiotropium is more effective than the β2-agonist salmeterol in preventing exacerbations in patients with moderate-to-very-severe chronic obstructive pulmonary disease, according to a multicenter European study published in the New England Journal of Medicine. Read full article.

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FDA won't take action against pharmacies that compound Makena

FDA said it wouldn't take action against compounding pharmacies that continue to supply 17-alpha hydroxyprogesterone caproate (Makena, KV Pharmaceutical, Ther-Rx). Read full article.

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Rheumatic disease patients may require 2 doses of flu vaccine

Patients with inflammatory rheumatic disease may need 2 doses of adjuvanted split influenza A vaccine to elicit the same antibody response as healthy individuals, reported a recent Swiss study published in Arthritis & Rheumatism. Read full article.

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