Dry eye syndrome, also known as keratoconjunctivitis sicca (KCS), is a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance, and tear film instability with potential damage to the ocular surface. Epidemiological studies have demonstrated that approximately 6% of the U.S. population complains of dry eye symptoms; this prevalence increases to 15% in adults older than 65 years of age. While no uniform criteria exist for the diagnosis of dry eye, multiple combinations of diagnostic tests may be used to assess symptoms and clinical signs of the condition. Studies have highlighted several promising pharmacologic agents for the treatment of dry eye, including the anti-CD4 monoclonal antibody, systemic linoleic and gamma-linoleic acids, and omega-3 essential fatty acids.
Upon completion of this text-based activity, participants should be able to:
• Identify the treatment algorithms used to combat the rising prevalence of dry eye in the United States, pinpointing any ethnic and geographic disparities responsible for this increase in order to rationalize earlier prescription treatment vs. over-the-counter usage
• Assess the pharmacoeconomic and treatment implications of dry eye, as well as the optimal conditions of the surface of the eye pre- and post-surgery
• Weigh the risks vs. benefits of currently approved and late-stage pipeline agents used for the treatment of dry eye conditions and implement strategy models to help improve patient care.
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