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In our March issue:
COLUMNS
LC TROUBLESHOOTING
Listen to the Data
John Dolan describes a stepwise process to help isolate and identify the cause of a method failure. |
GC CONNECTIONS
Gas Chromatography Ovens
The transit of peaks through a gas chromatography (GC) column depends strongly on the thermal profile they encounter on the way. Gas chromatographers primarily rely on the classic hot‑air‑bath type of oven, but several alternatives are also in use. This instalment from John Hinshaw examines ovens for GC in several forms plus how oven thermals affect peak retention behaviour. |
COLUMN WATCH
The Possibilities and Pitfalls of SFC
There has been a revival of supercritical fluid chromatography (SFC) in recent years, especially in the chiral preparative field, but also more recently in the analytical area. However, SFC is considerably more complex than liquid chromatography (LC), mainly because of the compressibility of the mobile phase. One can say that SFC is a “rubber variant” of LC where everything considered constant in LC varies in SFC. In this review, we go through advances in theory, instrumentation, and novel applications. |
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PEER-REVIEWED ARTICLE
Translating Methods from HPLC to UHPLC
The numerous advantages of translating gradient chromatographic methods between the differing formats of LC are explored and discussed. Various potential pitfalls may result in selectivity differences, changes in efficiency, and failure to meet resolution system suitability criteria.
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