COLUMNS
SAMPLE PREP PERSPECTIVES
The Greening of the Chromatography Laboratory
Ronald E. Majors and Douglas Raynie
Miniaturization and solvent substitution are two key approaches.

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LC TROUBLESHOOTING
A Picture Is Worth a Thousand Words
Kasper Pedersen and John W. Dolan
A few simple calculations and estimates can provide insight into a troublesome chromatogram.

MS—THE PRACTICAL ART
Problem Solving in the Chemical Industry
Michael P. Balogh
Identifying unknown compounds continues to challenge analysts.

ADVERTISEMENT Empower 3 Chromatography Software: New Tools and Calculation Capabilities to Enhance Productivity Tuesday, February 22, 2011 at 11:00 AM EST Waters® Empower™ 3 is the latest version of Waters’ chromatography software suite that provides several usability and workflow enhancements that will help improve laboratory productivity. Attendees of this webinar will learn about key features and benefits of Empower 3. Register Free: http://chromatographyonline.com/Empower3

THE HISTORY OF CHROMATOGRAPHY
Still a Young Technology, Chiral Chromatography Makes Big Strides in Pharma
Pilar Franco
Chiral chromatography is now the fastest way to access large amounts of enantiopure pharmaceutical compounds.

A Rapid and Space-Saving Method for Determining Melamine in Milk Under Organic Solvent–Free Conditions
Naoto Furusawa
High recovery, reproducibility, and cost savings are among the advantages of this environmentally friendly method.

Aggregated Singletons for Automated Purification Workflow
Bhagyashree A. Khunte and Laurence Philippe
A multistep workflow process provides purified samples for in-vitro testing in just two or three business days.

An Emerging Leader: One Year Later
Megan Evans
An interview with Jared Anderson of the University of Toledo.

WEBCASTS

New Approaches to High Sensitivity Dried Matrix Spot Sampling in Regulated Bioanalysis
LIVE WEBCAST: Wednesday, February 16, 2011 at 11:00 AM EST
This webcast will provide an overview of the latest workflows and software tools for highly sensitive and reproducible dried matrix spot sampling techniques using a novel low-flow HPLC approach in combination with a high sensitivity tandem mass spectrometer to enhance the wide spread applicability and robustness of DBS in the regulated bioanalysis industry.
» Register Free

Empower 3 Chromatography Software: New Tools and Calculation Capabilities to Enhance Productivity
LIVE WEBCAST: Tuesday, February 22, 2011 at 11:00 AM EST
Waters® Empower™ 3 is the latest version of Waters’ chromatography software suite that provides several usability and workflow enhancements that will help improve laboratory productivity. Attendees of this webinar will learn about key features and benefits of Empower 3.
» Register Free

Implementing Ultra-high-pressure LC (UHPLC): Perspective, Performance, Practice and Potential Issues
LIVE WEBCAST: Thursday, February 24, 2011 at 11:00 AM EST; 16:00 GMT
This webinar provides an overview on how to implement UHPLC in your laboratory for research and quality control applications. Topics will include an introduction to the technology, performance enhancements, its impacts on method development and sample analysis, implementation strategies, potential issues and how to mitigate operational nuances and pitfalls. Case studies are drawn from pharmaceutical analysis examples to illustrate benefits and best practice of UHPLC.
» Register Free

The CHROMacademy Essential Guide to Electrospray Ionization (ESI) for LC-MS (Part 1)
LIVE WEBCAST: Monday, February 28, 2011 at 11:00 AM EST
Understanding Electrospray Ionisation (ESI) for LC-MS

• Overview of ESI Hardware
• When to use electrospray
• Eluents and eluent flow rate
• The nebulization process – key factors in optimizing instrument response
• Desolvation processes - ensuring efficient droplet desolvation
• Mechanisms for producing ions in the gas phase – optimizing sensitivity
• Quantitative aspects of ESI – droplet and gas phase processes leading to ion suppression / enhancement

Maximum Power and Confidence for Screening and Qual/Quan Analysis with High-Res, Accurate Mass LC-MS with Orbitrap Technology
LIVE WEBCAST: Tuesday, March 29, 2011 at 8:00 AM PST; 11:00 AM EST
This webinar is intended to exemplify the power of high resolution accurate mass (HRAM) technology of compound identification, screening and quantitative analysis for clinical research, environmental, food safety and pharmaceutical applications.
» Register Free